Acute undifferentiated leukemia

A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells, primarily in the bone marrow and blood, lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis, anemia, variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (lymphadenopathy, splenomegaly, hepatomegaly).

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Narrow down the case reports

Total: 26 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (4.0%)	28190861	Acute undifferentiated leukemia (stem cell acute leukemia) showing differentiation to Langerhans cell-like cells in lymph nodes. Fukuta T, Nakamoto S, Hashimoto Y, Tanaka T, Tokuyasu Y, Maruyama J, Omura H, Hino N, Kuwamoto S, Murakami I. Rinsho Ketsueki. 2017;58(1):26-31. [ Show abstract ] [ Hide abstract ]
		Leukemia
		CD1A CD33 CD34 CD7 DNTT KIT S100A1

		Acute Disease Bone Marrow Females Homo sapiens
1 (4.0%)	26914221	5-Azacitidine Monotherapy Followed by Related Haploidentical Hematopoietic Stem Cell Transplantation Achieves Durable Remission in a Pediatric Patient With Acute Undifferentiated Leukemia Refractory to High-Dose Chemotherapy. Polishchuk V, Khazal S, Berulava G, Roth M, Mahadeo KM. Pediatr Blood Cancer. 2016;63(6):1111-2. [ Show abstract ] [ Hide abstract ]
		Acute leukemia


		Antimetabolites, Antineoplastic Combined Modality Therapy Homo sapiens Induction Chemotherapy Maintenance Chemotherapy Male Remission Induction Transplantation, Homologous
1 (4.0%)	25673598	Blastic plasmacytoid dendritic cell neoplasm: report of two pediatric cases. Dharmani PA, Mittal NM, Subramanian PG, Galani K, Badrinath Y, Amare P, Gujral S. Indian J Pathol Microbiol. 2015;58(1):72-6. [ Show abstract ] [ Hide abstract ]
		Leukemia
		CD33 CD34 CD4 CLEC4C IL3RA NCAM1

		CD Antigens Child Dendritic Cells Females HLA-DR Antigens Homo sapiens Immunophenotyping Lectins, C-Type Membrane Glycoproteins Receptors, Immunologic
1 (4.0%)	24987945	A Case of Subacute Encephalopathy Developing After Treatment With Clofarabine and Methotrexate That Resolved With Corticosteroids. Tzachanis D, Haider M, Papazisis G. Am J Ther. 2016;23(3):e937-40. [ Show abstract ] [ Hide abstract ]
		Dysarthria


		Adenine Nucleotides Adrenal Cortex Hormones Antineoplastic Combined Chemotherapy Protocols Arabinonucleosides Combination Drug Therapy Females Homo sapiens Neurotoxicity Syndromes Young Adult
1 (4.0%)	22937302 (3420675)	Prethymic cytoplasmic CD3 negative acute lymphoblastic leukemia or acute undifferentiated leukemia: a case report. Cannizzo E, Carulli G, Del Vecchio L, Azzara A, Galimberti S, Ottaviano V, Preffer F, Petrini M. Case Rep Hematol. 2011;2011:230568. [ Show abstract ] [ Hide abstract ]
		Leukemia



1 (4.0%)	20804920	Acute myeloid leukemia associated with t(10;17)(p13-15;q12-21) and phagocytic activity by leukemic blasts: a clinical study and review of the literature. Oh SH, Park TS, Cho SY, Kim MJ, Huh J, Kim B, Song SA, Lee JY, Jun KR, Shin JH, Kim HR, Lee JN. Cancer Genet Cytogenet. 2010;202(1):43-6. [ Show abstract ] [ Hide abstract ]
		Acute leukemia


		Adult Antimetabolites, Antineoplastic Blast Phase CD Antigens Child Chromosome Mapping Chromosomes, Human, Pair 10 Chromosomes, Human, Pair 17 Females Homo sapiens Magnetic Resonance Imaging Male Middle Aged Phagocytes
1 (4.0%)	20513125	Mixed phenotype acute leukemia with t(11;19)(q23;p13.3)/ MLL-MLLT1(ENL), B/T-lymphoid type: A first case report. Naghashpour M, Lancet J, Moscinski L, Zhang L. Am J Hematol. 2010;85(6):451-4. [ Show abstract ] [ Hide abstract ]
		Leukemia
		KMT2A MLLT1

		Acute Disease Adult Antigens, Neoplasm Bone Marrow CD Antigens Cell Lineage Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 19 Fluorescent in Situ Hybridization Gene Rearrangement Homo sapiens Immunophenotyping Male Myeloid-Lymphoid Leukemia Protein Neoplasm Proteins Nuclear Proteins Oncogene Proteins, Fusion
1 (4.0%)	12972810	Voriconazole treatment of presumptive disseminated Aspergillus infection in a child with acute leukemia. Shouldice E, Fernandez C, McCully B, Schmidt M, Fraser R, Cook C. J Pediatr Hematol Oncol. 2003;25(9):732-4. [ Show abstract ] [ Hide abstract ]
		Acute leukemia


		Acute Disease Antifungal Agents Aspergillosis Combination Drug Therapy Combined Modality Therapy Debridement Females Hepatitis Homo sapiens Lung Diseases, Fungal Opportunistic Infections Osteomyelitis Pyrimidines Remission Induction Splenic Diseases Triazoles
1 (4.0%)	7014488	Leukemic optic neuropathy. Brown GC, Shields JA, Augsburger JJ, Serota FT, Koch P. Int Ophthalmol. 1981;3(2):111-6. [ Show abstract ] [ Hide abstract ]
		Blindness


		Blindness Bone Marrow Transplantation Child Homo sapiens Male Retina Transplantation, Homologous
1 (4.0%)	6955174	Discordant 99mTc sulfur colloid and 67Ga-citrate scintigrams in Aspergillus splenic abscesses. Shih WJ, Domstad PA, DeLand FH. Eur J Nucl Med. 1982;7(6):272-4. [ Show abstract ] [ Hide abstract ]
		Fever


		Abscess Acute Disease Adult Aspergillosis Gallium Radioisotopes Homo sapiens Male Radionuclide Imaging Splenic Diseases Technetium

Phenotype(s) retrieved from Orphanet

Total: 0

HPO ID	Term	Frequency

Phenotype(s) retrieved from case reports

Total: 9

HPO ID	Term	# of case reports
HP:0001909	Leukemia	5
HP:0002488	Acute leukemia	3
HP:0011974	Myelofibrosis	2
HP:0000618	Blindness	1
HP:0001260	Dysarthria	1
HP:0001269	Hemiparesis	1
HP:0001298	Encephalopathy	1
HP:0001945	Fever	1
HP:0002027	Abdominal pain	1

Causative gene(s) retrieved from Orphanet

Total: 1

Gene Symbol	Gene Name	Entrez Gene ID
KMT2A	lysine methyltransferase 2A	4297