Acute undifferentiated leukemia

A rare acute leukemia of ambiguous lineage characterized by clonal proliferation of primitive hematopoietic cells, primarily in the bone marrow and blood, lacking lineage-specific markers and detectable genotypic alterations. The patients present with leukocytosis, anemia, variable platelet count and a variety of nonspecific symptoms related to ineffective hematopoesis (fatigue, bleeding and bruising, recurrent infections, bone pain) and/or extramedullary site involvement (lymphadenopathy, splenomegaly, hepatomegaly).



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Total: 26 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(4.0%)		 3518922
 Differential effects of phorbol esters on normal myeloid precursors and leukemic cells: basis for autologous bone marrow reconstitution in acute nonlymphocytic leukemia using phorbol ester-treated bone marrow from patients in remission.
Abrahm JL, Gerson SL, Hoxie JA, Tannenbaum SH, Cassileth PA, Cooper RA.
Cancer Res. 1986;46(7):3711-6.
Leukemia
Biologic Preservation Bone Marrow Bone Marrow Cells Bone Marrow Transplantation Cell Cycle Colony-Forming Units Assay Combined Modality Therapy Cultured Cells Dose-Response Relationship, Drug Freezing Hematopoiesis Homo sapiens Leukemia, Myelocytic, Acute Phorbols Tetradecanoylphorbol Acetate Time Factors
1
(4.0%)		 3465986
 Essential thrombocythemia and leukemic transformation.
Sedlacek SM, Curtis JL, Weintraub J, Levin J.
Medicine (Baltimore). 1986;65(6):353-64.
Leukemia
Adult Bone Marrow Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged Myeloid Leukemia Neoplastic Cell Transformation Thrombocythemia, Essential
1
(4.0%)		 3463212
 Immunophenotypic transformation from acute undifferentiated leukemia to Burkitt's-like acute lymphoblastic leukemia.
Burck KB, Levitt LJ.
Am J Med. 1986;81(3):551-4.
Pancytopenia
IGKV7-3
Acute Disease Adult Antineoplastic Combined Chemotherapy Protocols Homo sapiens Male Neoplastic Cell Transformation Phenotype
1
(4.0%)		 2782565
 Identification of myeloid origin in undifferentiated congenital leukemia by in vitro marrow culture study.
Kojima S, Mimaya J, Tonouchi T, Eguchi M, Osada H, Ueda R.
Am J Pediatr Hematol Oncol. 1989;11(3):337-42.
Leukemia
Antineoplastic Combined Chemotherapy Protocols Bone Marrow Cultured Cells DNA Nucleotidylexotransferase Electron Microscopy Females Gene Rearrangement Gene Rearrangement, T-Lymphocyte Homo sapiens Immunoglobulins Infant Membrane Proteins Myeloid Leukemia Tumor Stem Cell Assay
1
(4.0%)		 1747868
 Trisomy 13 as a primary chromosome aberration in acute leukemia.
Mertens F, Sallerfors B, Heim S, Johansson B, Kristoffersson U, Malm C, Mitelman F.
Cancer Genet Cytogenet. 1991;56(1):39-44.
Leukemia
Acute Disease Chromosome Banding Chromosomes, Human, Pair 13 Females Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged Trisomy
1
(4.0%)		 979874
 [Acute leukemia as terminal stage of Hodgkin's disease (author's transl)].
Ehler R, Meyer P, Hartwich G.
Med Klin. 1976;71(41):1740-3.
Leukemia
Acute Disease Antineoplastic Agents Bone Marrow Bone Marrow Cells Females Hodgkin Disease Homo sapiens Middle Aged
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 9

HPO ID Term # of case reports
HP:0001909 Leukemia 5
HP:0002488 Acute leukemia 3
HP:0011974 Myelofibrosis 2
HP:0000618 Blindness 1
HP:0001260 Dysarthria 1
HP:0001269 Hemiparesis 1
HP:0001298 Encephalopathy 1
HP:0001945 Fever 1
HP:0002027 Abdominal pain 1


Causative gene(s) retrieved from Orphanet

    Total: 1

Gene Symbol Gene Name Entrez Gene ID
KMT2A lysine methyltransferase 2A 4297