Chronic beryllium disease

Chronic beryllium disease (CBD) is a granulomatous, interstitial lung disease that occurs in individuals who develop beryllium sensitization (BeS), a cell-mediated immune response to environmental and occupational beryllium exposure. BeS precedes the lung disease that may present with chronic dry cough, fatigue, weight loss, chest pain, and increasing dyspnea.

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Narrow down the case reports

Total: 34 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (21.2%)	14644669 (1241769)	Silica exposure and systemic vasculitis. Mulloy KB. Environ Health Perspect. 2003;111(16):1933-8. [ Show abstract ] [ Hide abstract ]
		Glomerulonephritis Rheumatoid arthritis


		Arthralgia Complex Mixtures Glomerulonephritis Homo sapiens Male Middle Aged Military Personnel New Mexico Occupational Diseases Occupational Exposure Vasculitis Warfare
2 (4.0%)	30358624	Prostate-Specific Membrane Antigen-Positive Manifestations of Chronic Beryllium Lung Disease. Huang K, Baur AD, Furth C. Clin Nucl Med. 2019;44(1):64-65. [ Show abstract ] [ Hide abstract ]
		Lymphadenopathy


		Berylliosis Gallium Isotopes Gallium Radioisotopes Homo sapiens Male Oligopeptides Radiopharmaceuticals
2 (4.0%)	29374638	Fluctuating hypercalcaemia caused by cavitary Mycobacterium bovis pulmonary infection. Moloney DP, Chawke L, Crowley MT, O'Connor TM. BMJ Case Rep. 2018;2018:. [ Show abstract ] [ Hide abstract ]
		Pneumonia


		Antitubercular Agents Homo sapiens Hypercalcemia Male Middle Aged Mycobacterium bovis Tuberculosis, Pulmonary
2 (4.0%)	27379608	Sudden unexpected death due to severe pulmonary and cardiac sarcoidosis. Ginelliova A, Farka D, Farkaova Iannaccone S, Vyhnalkova V. Forensic Sci Med Pathol. 2016;12(3):319-23. [ Show abstract ] [ Hide abstract ]
		Nausea


		Arteritis Cardiomyopathies Coronary Vessels Females Homo sapiens Middle Aged Myocardial Ischemia Sarcoidosis Sarcoidosis, Pulmonary
2 (4.0%)	27330955 (4901174)	Elemental analysis of occupational granulomatous lung disease by electron probe microanalyzer with wavelength dispersive spectrometer: Two case reports. Tomioka H, Kaneda T, Katsuyama E, Kitaichi M, Moriyama H, Suzuki E. Respir Med Case Rep. 2016;18:66-72. [ Show abstract ] [ Hide abstract ]
		Interstitial pneumonitis



2 (4.0%)	25668608	[Epitheloid cell granulomas in bronchial invasive mucinous adenocarcinoma]. Grunewaldt A, Wagner TO. Pneumologie. 2015;69(2):89-92. [ Show abstract ] [ Hide abstract ]
		Pneumonia


		Bronchial Neoplasms Differential Diagnosis Granuloma Homo sapiens Male Mucinous Adenocarcinoma Neoplasm Invasiveness
2 (4.0%)	22503169	Schaumann bodies in Crohn's disease: a case report and review of the literature. Lorenzi L, Bisoffi Z, Bortesi L, Zamboni G, Liut F, Villanacci V. J Crohns Colitis. 2012;6(7):800-3. [ Show abstract ] [ Hide abstract ]
		Colitis


		Calcinosis Colonic Diseases Crohn Disease Diagnostic Errors Females Homo sapiens Middle Aged
2 (4.0%)	21760475	Hypercalcemia in two patients with sarcoidosis and Mycobacterium avium intracellulare not mediated by elevated vitamin D metabolites. Shrayyef MZ, DePapp Z, Cave WT, Wittlin SD. Am J Med Sci. 2011;342(4):336-40. [ Show abstract ] [ Hide abstract ]
		Hypercalcemia
		PTH

		AIDS-Related Opportunistic Infections Adult Feedback, Physiological Homo sapiens Hypercalcemia Male Middle Aged Mycobacterium avium-intracellulare Infection Sarcoidosis
2 (4.0%)	19960785	Long-term complications and prognosis of chronic beryllium disease. Handa T, Nagai S, Kitaichi M, Chin K, Ito Y, Oga T, Takahashi K, Watanabe K, Mishima M, Izumi T. Sarcoidosis Vasc Diffuse Lung Dis. 2009;26(1):24-31. [ Show abstract ] [ Hide abstract ]
		Cor pulmonale


		Adult Anti-Infective Agents Berylliosis Females Homo sapiens Lung Male Middle Aged Pneumonectomy Pneumothorax Remission Induction Respiratory Tract Infections Retrospective Studies Steroids Time Factors Young Adult
2 (4.0%)	19672405 (2721869)	A reconsideration of acute Beryllium disease. Cummings KJ, Stefaniak AB, Virji MA, Kreiss K. Environ Health Perspect. 2009;117(8):1250-6. [ Show abstract ] [ Hide abstract ]
		Granuloma


		Adult Air Pollutants, Occupational Berylliosis Homo sapiens Hypersensitivity Male Radioactive Pollutants Respiratory System Skin Young Adult

Phenotype(s) retrieved from Orphanet

Total: 0

HPO ID	Term	Frequency

Phenotype(s) retrieved from case reports

Total: 9

HPO ID	Term	# of case reports
HP:0032252	Granuloma	7
HP:0002955	Granulomatosis	2
HP:0003072	Hypercalcemia	2
HP:0002090	Pneumonia	1
HP:0002110	Bronchiectasis	1
HP:0002617	Dilatation	1
HP:0002789	Tachypnea	1
HP:0012819	Myocarditis	1
HP:0030250	Pulmonary granulomatosis	1

Causative gene(s) retrieved from Orphanet

Total: 1

Gene Symbol	Gene Name	Entrez Gene ID
HLA-DPB1	major histocompatibility complex, class II, DP beta 1	3115