Choroid plexus carcinoma

Choroid plexus carcinoma is a rare and highly aggressive malignant type of choroid plexus tumor (see this term) occurring almost exclusively in children, presenting with cerebrospinal fluid obstruction in the lateral ventricles (most common), the fourth and third ventricles or in multiple ventricles, leading to hydrocephalus and increased intracranial pressure, and manifesting with nausea, vomiting, abnormal eye movements, gait impairment, seizures and enlarged head circumference.



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Total: 77 (papers)

   


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Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(39.0%)		 492463
 [Choroid plexus carcinoma with metastasis to bone (author's transl)].
Hayakawa I, Fujiwara K, Tsuchida T, Aoki M.
No Shinkei Geka. 1979;7(8):815-8.
Increased head circumference
Cerebral Ventricle Neoplasms Ependymoma Females Homo sapiens Infant
2
(4.0%)		 31062532
 Choroid Plexus Carcinoma in Adults: Two Case Reports.
Kim T, Park MR, Hong EK, Gwak HS.
Brain Tumor Res Treat. 2019;7(1):48-52.
Edema
2
(4.0%)		 28792797
 Magnetic Resonance Imaging and Clinical Findings Associated with Choroid Plexus Spinal Cord "Drop" Metastases.
Yeamans CL, Gutierrez-Quintana R, Haley A, Lamm CG.
J Am Anim Hosp Assoc. 2017;53(5):265-269.
Paraparesis
Animals Canis familiaris Dog Diseases Fatal Outcome Magnetic Resonance Imaging Male Spinal Cord Neoplasms
2
(4.0%)		 28607820
(5461574)
 Incidental choroid plexus papilloma in a child: A difficult decision.
Laarakker AS, Nakhla J, Kobets A, Abbott R.
Surg Neurol Int. 2017;8:86.
Hydrocephalus
2
(4.0%)		 28460341
 A rare case of choroid plexus carcinoma that led to the diagnosis of Lynch syndrome (hereditary nonpolyposis colorectal cancer).
Zhu VW, Hinduja S, Knezevich SR, Silveira WR, DeLozier CD.
Clin Neurol Neurosurg. 2017;158:46-48.
Colon cancer
MLH1 MSH2 MSH6 NOTCH1 PMS2 PTEN RB1 TP53 VHL
p|SUB|R|482|* rs63750909
Carcinoma Choroid Plexus Neoplasms DNA-Binding Proteins Females Hereditary Nonpolyposis Colorectal Neoplasms Homo sapiens
2
(4.0%)		 28413558
(5379790)
 Choroid plexus papilloma.
Sethi D, Arora R, Garg K, Tanwar P.
Asian J Neurosurg. 2017;12(1):139-141.
Neoplasm
2
(4.0%)		 26248671
 Pre-operative embolization of a choroid plexus carcinoma: review of the vascular anatomy.
Slater LA, Hoffman C, Drake J, Krings T.
Childs Nerv Syst. 2016;32(3):541-5.
Hydrocephalus
Carcinoma Choroid Plexus Neoplasms Embolization, Therapeutic Females Homo sapiens Infant
2
(4.0%)		 26161225
(4489946)
 Choroid plexus carcinoma in adults: an extremely rare case.
Ozdogan S, Gergin YE, Gergin S, Senol O, Tiryaki M, Tatarli N, Hicdonmez T.
Pan Afr Med J. 2015;20:302.
Hydrocephalus
Age Factors Carcinoma Choroid Plexus Neoplasms Headache Homo sapiens Magnetic Resonance Imaging Male X-Ray Computed Tomography
2
(4.0%)		 25723725
 Neoadjuvant chemotherapy for brain tumors in infants and young children.
Iwama J, Ogiwara H, Kiyotani C, Terashima K, Matsuoka K, Iwafuchi H, Morota N.
J Neurosurg Pediatr. 2015;15(5):488-92.
Ependymoma
Antineoplastic Combined Chemotherapy Protocols Brain Neoplasms Carcinoma Child Child, Preschool Choroid Plexus Neoplasms Drug Administration Schedule Embryonal Carcinoma Ependymoma Females Glioblastoma Homo sapiens Infant Magnetic Resonance Imaging Male Neoadjuvant Therapy Neuroectodermal Tumor, Primitive Retrospective Studies Rhabdoid Tumor Second Look Surgery
2
(4.0%)		 25063761
 Choroid plexus papilloma-A case highlighting the challenges of extrapolating pediatric chemotherapy regimens to adult populations.
Barman SL, Jean GW, Dinsfriend WM, Gerber DE.
J Oncol Pharm Pract. 2016;22(1):170-4.
Sepsis
Adult Antineoplastic Combined Chemotherapy Protocols Choroid Plexus Papilloma Females Homo sapiens Pediatrics
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 25

HPO ID Term # of case reports
HP:0002888 Ependymoma 7
HP:0002664 Neoplasm 4
HP:0030065 Primitive neuroectodermal tumor 4
HP:0001288 Gait disturbance 2
HP:0002861 Melanoma 2
HP:0030731 Carcinoma 2
HP:0000622 Blurred vision 1
HP:0000822 Hypertension 1
HP:0001085 Papilledema 1
HP:0001251 Ataxia 1
HP:0001260 Dysarthria 1
HP:0001269 Hemiparesis 1
HP:0001337 Tremor 1
HP:0001909 Leukemia 1
HP:0002018 Nausea 1
HP:0002385 Paraparesis 1
HP:0002863 Myelodysplasia 1
HP:0003764 Nevus 1
HP:0012740 Papilloma 1
HP:0030071 Medulloepithelioma 1
HP:0030692 Brain neoplasm 1
HP:0031925 Rosette 1
HP:0100242 Sarcoma 1
HP:0100620 Germinoma 1
HP:0100806 Sepsis 1


Causative gene(s) retrieved from Orphanet

    Total: 1

Gene Symbol Gene Name Entrez Gene ID
TP53 tumor protein p53 7157