Choroid plexus carcinoma

Choroid plexus carcinoma is a rare and highly aggressive malignant type of choroid plexus tumor (see this term) occurring almost exclusively in children, presenting with cerebrospinal fluid obstruction in the lateral ventricles (most common), the fourth and third ventricles or in multiple ventricles, leading to hydrocephalus and increased intracranial pressure, and manifesting with nausea, vomiting, abnormal eye movements, gait impairment, seizures and enlarged head circumference.

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Narrow down the case reports

Total: 77 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
2 (4.0%)	25034609	Intrauterine diagnosis and pathology of fetal choroid plexus carcinoma--a case study. Joo GJ, Reiniger L, Papp C, Csaba A, Komaromy H, Rigo J Jr. Pathol Res Pract. 2014;210(12):1156-9. [ Show abstract ] [ Hide abstract ]
		Hydrocephalus


		Adult Carcinoma Choroid Plexus Neoplasms Females Fetal Diseases Gestational Age Homo sapiens Magnetic Resonance Imaging
2 (4.0%)	24251760	Spitzoid melanoma in a child with Li-Fraumeni syndrome. Kollipara R, Cooley LD, Horii KA, Hetherington ML, Leboit PE, Singh V, Zwick DL. Pediatr Dev Pathol. 2014;17(1):64-9. [ Show abstract ] [ Hide abstract ]
		Melanoma
		TP53

		Carcinoma Choroid Plexus Neoplasms Germ-Line Mutation Homo sapiens Infant Li-Fraumeni Syndrome Male Skin Skin Neoplasms
2 (4.0%)	23427033	Recurrent adult choroid plexus carcinoma treated with high-dose chemotherapy and syngeneic stem cell (bone marrow) transplant. Samuel TA, Parikh J, Sharma S, Giller CA, Sterling K, Kapoor S, Pirkle C, Jillella A. J Neurol Surg A Cent Eur Neurosurg. 2013;74 Suppl 1:e149-54. [ Show abstract ] [ Hide abstract ]
		Brain neoplasm


		Acoustic Neuroma Antineoplastic Agents Bone Marrow Transplantation Carcinoma Cerebellar Neoplasms Chemoradiotherapy Choroid Plexus Neoplasms Disease-Free Survival Fatal Outcome Females Homo sapiens Magnetic Resonance Imaging Palliative Care Seizures Young Adult
2 (4.0%)	23151741	Pseudoprogression after proton beam irradiation for a choroid plexus carcinoma in pediatric patient: MRI and PET imaging patterns. Korchi AM, Garibotto V, Ansari M, Merlini L. Childs Nerv Syst. 2013;29(3):509-12. [ Show abstract ] [ Hide abstract ]
		Tremor


		Blood Volume Brain Carcinoma Cerebrovascular Circulation Child Choroid Plexus Neoplasms Combined Modality Therapy Disease Progression Females Homo sapiens Magnetic Resonance Imaging Positron-Emission Tomography Proton Therapy
2 (4.0%)	22534715 (3560637)	A novel TP53 somatic mutation involved in the pathogenesis of pediatric choroid plexus carcinoma. Lv SQ, Song YC, Xu JP, Shu HF, Zhou Z, An N, Huang QL, Yang H. Med Sci Monit. 2012;18(5):CS37-41. [ Show abstract ] [ Hide abstract ]
		Hypertension
		CHGA GFAP PROM1 SLC4A1 SLC4A3 SMARCB1 TP53
		p\|SUB\|R\|248\|Q;RS#:11540652
		Child, Preschool Choroid Plexus Neoplasms Fatal Outcome Germ-Line Mutation Homo sapiens Immunohistochemistry Male
2 (4.0%)	22346199 (3271623)	Choroid plexus carcinoma in an adult. Kishore S, Negi G, Meena H, Anuradha K, Pathak PV, Bansal K. J Neurosci Rural Pract. 2012;3(1):71-3. [ Show abstract ] [ Hide abstract ]
		Carcinoma
		TP53


2 (4.0%)	21972189	[A case of metastatic choroid plexus tumor from cholangiocellular carcinoma]. Kurisu K, Kamoshima Y, Terasaka S, Kobayashi H, Kubota K, Houkin K. No Shinkei Geka. 2011;39(10):991-7. [ Show abstract ] [ Hide abstract ]
		Carcinoma
		PTGER4

		Bile Duct Neoplasms Cholangiocarcinoma Choroid Plexus Neoplasms Females Homo sapiens Middle Aged
2 (4.0%)	21442238	MGMT promoter methylation and temozolomide response in choroid plexus carcinoma. Misaki K, Nakada M, Mohri M, Hayashi Y, Hamada J. Brain Tumor Pathol. 2011;28(3):259-63. [ Show abstract ] [ Hide abstract ]
		Hydrocephalus
		MGMT

		Adult Antineoplastic Agents, Alkylating Brain Neoplasms Chemoradiotherapy, Adjuvant Choroid Plexus Neoplasms DNA Methylation Homo sapiens Hydrocephalus Magnetic Resonance Imaging Male O(6)-Methylguanine-DNA Methyltransferase Promoter Regions, Genetic
2 (4.0%)	21099705	Multiple epidural hematomas and hemodynamic collapse caused by a subgaleal drain and suction-induced intracranial hypotension: case report. Roth J, Galeano E, Milla S, Hartmannsgruber MW, Weiner HL. Neurosurgery. 2011;68(1):E271-5; discussion E276. [ Show abstract ] [ Hide abstract ]
		Bradycardia


		Carcinoma Child, Preschool Choroid Plexus Neoplasms Hematoma, Epidural, Cranial Hemodynamics Homo sapiens Intracranial Hypotension Male Neurosurgical Procedures
2 (4.0%)	21070306	Choroid plexus carcinoma cells in the cerebrospinal fluid of a Staffordshire Bull Terrier. Pastorello A, Constantino-Casas F, Archer J. Vet Clin Pathol. 2010;39(4):505-10. [ Show abstract ] [ Hide abstract ]
		Papilledema


		Animals Brain Stem Canis familiaris Choroid Plexus Neoplasms Dog Diseases Epithelium Females Magnetic Resonance Imaging

Phenotype(s) retrieved from Orphanet

Total: 0

HPO ID	Term	Frequency

Phenotype(s) retrieved from case reports

Total: 25

HPO ID	Term	# of case reports
HP:0002888	Ependymoma	7
HP:0002664	Neoplasm	4
HP:0030065	Primitive neuroectodermal tumor	4
HP:0001288	Gait disturbance	2
HP:0002861	Melanoma	2
HP:0030731	Carcinoma	2
HP:0000622	Blurred vision	1
HP:0000822	Hypertension	1
HP:0001085	Papilledema	1
HP:0001251	Ataxia	1
HP:0001260	Dysarthria	1
HP:0001269	Hemiparesis	1
HP:0001337	Tremor	1
HP:0001909	Leukemia	1
HP:0002018	Nausea	1
HP:0002385	Paraparesis	1
HP:0002863	Myelodysplasia	1
HP:0003764	Nevus	1
HP:0012740	Papilloma	1
HP:0030071	Medulloepithelioma	1
HP:0030692	Brain neoplasm	1
HP:0031925	Rosette	1
HP:0100242	Sarcoma	1
HP:0100620	Germinoma	1
HP:0100806	Sepsis	1

Causative gene(s) retrieved from Orphanet

Total: 1

Gene Symbol	Gene Name	Entrez Gene ID
TP53	tumor protein p53	7157