IgG4-related kidney disease

A rare renal disease occurring in the setting of a systemic IgG4 related disease. Renal manifestations include tubulointerstitial nephritis (TIN), membranous glomerulonephritis with or without TIN, IgA nephropathy, membranoproliferative glomerulonephritis, mesangioproliferative immune complex glomerulonephritis, sclerosing pyelitis, IgG4-related plasma cell arteritis, and hydronephrosis associated with IgG4 related retroperitoneal fibrosis or ureteral inflammatory pseudotumor. Patients present with acute or chronic renal failure and radiographic mass lesion.



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Total: 28 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
3
(4.0%)		 25861230
(4360849)
 A Case of IgG4-Related Hypophysitis Presented with Hypopituitarism and Diabetes Insipidus.
Harano Y, Honda K, Akiyama Y, Kotajima L, Arioka H.
Clin Med Insights Case Rep. 2015;8:23-6.
Hypogonadism
3
(4.0%)		 25371379
 Tubulointerstitial fibrosis in patients with IgG4-related kidney disease: pathological findings on repeat renal biopsy.
Arai H, Hayashi H, Takahashi K, Koide S, Sato W, Hasegawa M, Yamaguchi Y, Aten J, Ito Y, Yuzawa Y.
Rheumatol Int. 2015;35(6):1093-101.
Tubulointerstitial nephritis
ACTA1 CCN2
Adrenal Cortex Hormones Adult Biological Markers Biopsy Diabetes Mellitus, Insulin-Dependent Disease Progression Females Fibrosis Homo sapiens Immunohistochemistry Male Middle Aged Nephritis, Interstitial Plasma Cells Severity of Illness Index Time Factors
3
(4.0%)		 25038818
(4107474)
 IgG4-related tubulointerstitial nephritis accompanied with cystic formation.
Fukuhara H, Taniguchi Y, Matsumoto M, Kuroda N, Fukata S, Inoue K, Fujimoto S, Terada Y, Shuin T.
BMC Urol. 2014;14:54.
Tubulointerstitial nephritis
Cystic Kidney Diseases Differential Diagnosis Females Homo sapiens Immunohistochemistry Kidney Kidney Neoplasm Middle Aged Nephritis, Interstitial Positron-Emission Tomography Radiopharmaceuticals Renal Cell Carcinoma X-Ray Computed Tomography
3
(4.0%)		 24842825
 A case of IgG4-positive plasma cell-rich tubulointerstitial nephritis in a kidney allograft mimicking IgG4-related kidney disease.
Nishikawa K, Takeda A, Masui S, Kanda H, Yamada Y, Arima K, Morozumi K, Sugimura Y.
Nephrology (Carlton). 2014;19 Suppl 3:52-6.
Nephropathy
ABO
Differential Diagnosis Females Homo sapiens Immunoglobulin kappa-Chains Kidney Transplantation Lymphoproliferative Disorders Middle Aged Nephritis, Interstitial Plasma Cells Steroids Transplantation, Homologous
3
(4.0%)		 24842479
 A case of ANCA-negative renal small-vessel vasculitis with tubulointerstitial infiltration of IgG4-positive plasma cells.
Sakairi T, Okabe S, Hiromura K, Motegi S, Sakurai N, Ikeuchi H, Kaneko Y, Maeshima A, Hirato J, Nojima Y.
Mod Rheumatol. 2016;26(5):780-3.
Tubulointerstitial nephritis
CRP
Antineutrophil Cytoplasmic Antibodies Homo sapiens Kidney Male Middle Aged Plasma Cells Vasculitis
3
(4.0%)		 23896119
 Testicular inflammation as a new manifestation of IgG4-associated disease.
de Buy Wenniger LM, Scheltema JM, Verheij J, Beuers U.
Urology. 2013;82(2):e15-6.
Prostatitis
Autoimmune Diseases Epididymitis Homo sapiens Hydronephrosis Male Middle Aged Orchiectomy Orchitis Pancreatitis Testis
3
(4.0%)		 22790135
 Possible IgG4-related kidney disease requiring a differential diagnosis of membranous lupus nephritis.
Yahata M, Takahashi S, Nakaya I, Sakuma T, Sato H, Soma J.
Intern Med. 2012;51(13):1731-6.
Proteinuria
Adult Antibodies, Antinuclear Differential Diagnosis Females Homo sapiens Kidney Diseases Kidney Glomerulus Lupus Nephritis Nephritis, Interstitial
3
(4.0%)		 22687796
 Churg-Strauss syndrome with a clinical condition similar to IgG4-related kidney disease: a case report.
Ayuzawa N, Ubara Y, Keiichi S, Masayuki Y, Hasegawa E, Hiramatsu E, Hayami N, Suwabe T, Hoshino J, Sawa N, Kawabata M, Ohashi K, Takaichi K.
Intern Med. 2012;51(10):1233-8.
Nephropathy
PRTN3
Females Homo sapiens Kidney Diseases Nephritis, Interstitial
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 11

HPO ID Term # of case reports
HP:0001970 Tubulointerstitial nephritis 5
HP:0000123 Nephritis 4
HP:0000024 Prostatitis 2
HP:0000099 Glomerulonephritis 2
HP:0012578 Membranous nephropathy 2
HP:0000083 Renal insufficiency 1
HP:0000793 Membranoproliferative glomerulonephritis 1
HP:0001919 Acute kidney injury 1
HP:0005576 Tubulointerstitial fibrosis 1
HP:0030151 Cholangitis 1
HP:0030731 Carcinoma 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID