Paget disease of the nipple

Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.



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Total: 55 (papers)

   


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Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(4.0%)		 2544464
 Paget's disease of the nipple occurring after wide local excision and radiotherapy for carcinoma of the breast.
Menzies D, Barr L, Ellis H.
Eur J Surg Oncol. 1989;15(3):271-3.
Breast carcinoma
Carcinoma in Situ Combined Modality Therapy Differential Diagnosis Females Homo sapiens Neoplasm Recurrence, Local Noninfiltrating Intraductal Carcinoma Paget's Disease, Mammary
1
(4.0%)		 2015924
 Florid papillomatosis of the nipple: a clinico-pathological surgical problem.
Scott P, Kissin MW, Collins C, Webb AJ.
Eur J Surg Oncol. 1991;17(2):211-3.
Carcinoma
Cystadenoma Females Homo sapiens Middle Aged Nipples
1
(4.0%)		 1318852
 The place for conservative treatment in the management of Paget's disease of the nipple.
el-Sharkawi A, Waters JS.
Eur J Surg Oncol. 1992;18(3):301-3.
Carcinoma
Aged, 80 and over Combined Modality Therapy Females Homo sapiens Middle Aged Nipples Paget's Disease, Mammary
1
(4.0%)		 547546
 [Adenoma of the nipples].
Marsch WC, Nurnberger F.
Z Hautkr. 1979;54(24):1067-72.
Indurated nodule
SYNM
Adenoma Differential Diagnosis Females Homo sapiens Middle Aged Nipples
1
(4.0%)		 216604
 [Carcinoma of the apocrine glands of the vulva with intraepidermal spreading under the picture of invasive Paget's disease (author's transl)].
Heberling D, Dohnert G, Rummel HH.
Geburtshilfe Frauenheilkd. 1979;39(2):101-5.
Carcinoma
Females Homo sapiens Lymphatic Metastasis Paget Disease Extramammary Vulvar Neoplasms
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 10

HPO ID Term # of case reports
HP:0030731 Carcinoma 15
HP:0002861 Melanoma 6
HP:0003002 Breast carcinoma 5
HP:0030075 Ductal carcinoma in situ 2
HP:0000964 Eczema 1
HP:0002664 Neoplasm 1
HP:0002860 Squamous cell carcinoma 1
HP:0012056 Cutaneous melanoma 1
HP:0012740 Papilloma 1
HP:0030076 Lobular carcinoma in situ 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID