Paget disease of the nipple

Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.

Input patient's signs and symptoms

Narrow down the case reports

Total: 55 (papers)

(per page)

Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (4.0%)	30110525	Sebaceous Carcinoma in Situ Masquerading Clinically and Histologically as Paget Disease of the Breast. Tjarks BJ, Kerkvliet AM, Jassim AD. S D Med. 2018;71(8):350-353. [ Show abstract ] [ Hide abstract ]
		Squamous cell carcinoma
		F13A1 KRT20 KRT7 MLANA PLIN2

		Carcinoma in Situ Differential Diagnosis Females Homo sapiens Immunohistochemistry Middle Aged Paget's Disease, Mammary Sebaceous Adenocarcinoma Sebaceous Gland Neoplasms
1 (4.0%)	30008979 (6043634)	Bilateral mammary Paget disease in a young adult female. Babu B, Dev B, Mohanapriya T, Shalini CNS. Radiol Case Rep. 2018;13(3):586-591. [ Show abstract ] [ Hide abstract ]
		Eczema



1 (4.0%)	29694313	Paget's disease of the male breast: case report and a point of view from actual literature. Vergine M, Musella A, Gulotta E, Frusone F, De Luca A, Maceli F, Libia A, Benedetti Panici P, Monti M. G Chir. 2018;39(2):114-117. [ Show abstract ] [ Hide abstract ]
		Carcinoma
		ERBB2

		Alzheimer's Disease Antineoplastic Agents, Hormonal Breast Neoplasms, Male Combined Modality Therapy Homo sapiens Male Mastectomy Neoplasms, Hormone-Dependent Neoplasms, Multiple Primary Nipples Noninfiltrating Intraductal Carcinoma Paget's Disease, Mammary Skin Ulcer
1 (4.0%)	29265587	Solid papillary carcinoma of the breast with an associated Cytokeratin 7- negative Paget's disease of the nipple. Report of a first case. Rupp NJ, Rodewald AK, Chiesa F, Varga Z. Breast J. 2018;24(4):637-641. [ Show abstract ] [ Hide abstract ]
		Carcinoma
		KRT7

		Adult Carcinoma, Papillary Females Homo sapiens Nipples Paget's Disease, Mammary
1 (4.0%)	28329595	Pigmented lesion of the nipple - a clinicopathological challenge. Vide J, Cesar A, Rodrigues Pereira P, Azevdo F. Dermatol Online J. 2016;22(10):. [ Show abstract ] [ Hide abstract ]
		Melanocytic nevus


		Adult Females Homo sapiens Hyperpigmentation Immunohistochemistry Melanoma-Specific Antigens Nipples Noninfiltrating Intraductal Carcinoma Paget's Disease, Mammary S100 Proteins gp100 Melanoma Antigen
1 (4.0%)	27206635 (4873987)	Nipple adenoma in a female patient presenting with persistent erythema of the right nipple skin: case report, review of the literature, clinical implications, and relevancy to health care providers who evaluate and treat patients with dermatologic conditions of the breast skin. Spohn GP, Trotter SC, Tozbikian G, Povoski SP. BMC Dermatol. 2016;16(1):4. [ Show abstract ] [ Hide abstract ]
		Erythema


		Adenoma Erythema Females Homo sapiens Middle Aged Nipples
1 (4.0%)	26990474	Multifocal extramammary Paget's disease-associated adenocarcinoma: a rare condition of flexoral skin of multiple sites. Wolf K, Stewart L, Rapini R, Mutyambizi K. Dermatol Online J. 2016;22(1):. [ Show abstract ] [ Hide abstract ]
		Acanthosis nigricans


		Adenocarcinoma Biopsy Differential Diagnosis Homo sapiens Male Middle Aged Paget Disease Extramammary Rare Diseases Skin Skin Neoplasms
1 (4.0%)	26489679	Invasive Paget Disease of the Nipple of Luminal-B Subtype With Axillary Lymph Node Metastasis in a 60-Year-Old White Woman. Saluja K, Sahoo S. Lab Med. 2015;46(4):332-7. [ Show abstract ] [ Hide abstract ]
		Papilloma
		ERBB2

		Females Homo sapiens Middle Aged Nipples Paget's Disease, Mammary Sentinel Lymph Node Biopsy
1 (4.0%)	26204599	Pigmented Paget's disease of the nipple. Szpor J, Polak K, Dyduch G, Okon K, Hodorowicz-Zaniewska D, Brzuzkiewicz K, Streb J. Pol J Pathol. 2015;66(1):93-7. [ Show abstract ] [ Hide abstract ]
		Melanoma


		Biomarkers, Tumor Biopsy Differential Diagnosis Females Homo sapiens Immunohistochemistry Melanins Middle Aged Nipples Paget's Disease, Mammary Predictive Value of Tests
1 (4.0%)	25775646	Pigmented Mammary Paget Disease Mimicking Superficial Spreading Melanoma in an Elderly African-American Female. Napolitano L, Crowe D. J Cutan Med Surg. 2015;19(3):313-6. [ Show abstract ] [ Hide abstract ]
		Cutaneous melanoma


		African American Differential Diagnosis Females Homo sapiens Nipples Paget's Disease, Mammary Skin

Phenotype(s) retrieved from Orphanet

Total: 0

HPO ID	Term	Frequency

Phenotype(s) retrieved from case reports

Total: 10

HPO ID	Term	# of case reports
HP:0030731	Carcinoma	15
HP:0002861	Melanoma	6
HP:0003002	Breast carcinoma	5
HP:0030075	Ductal carcinoma in situ	2
HP:0000964	Eczema	1
HP:0002664	Neoplasm	1
HP:0002860	Squamous cell carcinoma	1
HP:0012056	Cutaneous melanoma	1
HP:0012740	Papilloma	1
HP:0030076	Lobular carcinoma in situ	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID