Paget disease of the nipple

Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.



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Narrow down the case reports



Total: 55 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(4.0%)
25473229
(4252674)
Pigmented mammary paget disease misdiagnosed as malignant melanoma.
Lee JH, Kim TH, Kim SC, Kim YC, Roh MR.
Ann Dermatol. 2014;26(6):747-50.
Melanoma
1
(4.0%)
24583835
Invasive Paget disease of the nipple: a brief review of the literature and report of the first case with axillary nodal metastases.
Ozerdem U, Swistel A, Antonio LB, Hoda SA.
Int J Surg Pathol. 2014;22(6):566-9.
Lymphadenopathy
Axilla Females Homo sapiens Lymphatic Metastasis Neoplasms, Second Primary Nipples Paget's Disease, Mammary
1
(4.0%)
23714052
Primary squamous cell carcinoma of the nipple: a diagnosis of suspicion.
Sofos SS, Tehrani H, Lymperopoulos N, Constantinides J, James MI.
J Plast Reconstr Aesthet Surg. 2013;66(11):e315-7.
Squamous cell carcinoma
Adult Females Homo sapiens Nipples
1
(4.0%)
23661948
(3643369)
Pigmented Paget's disease of nipple: A diagnostic challenge on cytology.
Vani B, Thejaswini M, Srinivasamurthy V, Rao MS.
J Cytol. 2013;30(1):68-70.
Melanoma
ERBB2 S100A1
1
(4.0%)
23031371
Extramammary Paget disease: Immunohistochemistry is critical to distinguish potential mimickers.
Wang EC, Kwah YC, Tan WP, Lee JS, Tan SH.
Dermatol Online J. 2012;18(9):4.
Melanoma
Adenocarcinoma Biopsy Bowen's Disease Carcinoembryonic Antigen Diagnostic Errors Homo sapiens Immunohistochemistry MART-1 Antigen Male Mohs Surgery Neoplasm Grading Paget Disease Extramammary Prostate-Specific Antigen Prostatic Neoplasms Skin Neoplasms
1
(4.0%)
22920370
A rare case report of a primary large-cell neuroendocrine carcinoma of the breast with coexisting Paget disease.
Psoma E, Nikolaidou O, Stavrogianni T, Mavromati A, Lytras K, Xirou P, Koumbanaki M, Panagiotopoulou D.
Clin Imaging. 2012;36(5):599-601.
Carcinoma
Carcinoma, Large Cell Carcinoma, Neuroendocrine Combined Modality Therapy Differential Diagnosis Females Homo sapiens Mammography Middle Aged Paget's Disease, Mammary Ultrasonography, Mammary X-Ray Computed Tomography
1
(4.0%)
22895267
Invasive paget disease of the breast: clinicopathologic study of an underrecognized entity in the breast.
Duan X, Sneige N, Gullett AE, Prieto VG, Resetkova E, Andino LM, Wu Y, Gilcrease MZ, Bedrosian I, Dawood S, Arun B, Albarracin CT.
Am J Surg Pathol. 2012;36(9):1353-8.
Breast carcinoma
Adult Combined Modality Therapy Dermis Females Homo sapiens Mastectomy Middle Aged Neoplasm Invasiveness Noninfiltrating Intraductal Carcinoma Paget's Disease, Mammary
1
(4.0%)
22807966
Synchronous bilateral Paget's disease of the breast: A case report.
Xie B, Zheng H, Lan H, Cui B, Jin K, Cao F.
Oncol Lett. 2012;4(1):83-85.
Eczema
1
(4.0%)
22698908
An unusual presentation of breast cancer in a very young woman.
Sandhu NP, Long HJ, Johnson KJ, Degnim AC.
BMJ Case Rep. 2011;2011:.
Pruritus
Adult Females Homo sapiens Hyperpigmentation Nipples Paget's Disease, Mammary Pruritus
1
(4.0%)
22148050
(3229065)
Pigmented Basal cell carcinoma of the nipple-areola complex in an elderly woman.
Jung HJ, Jun JH, Kim HY, Lee SJ, Kim DW, Lee WJ, Jung JH.
Ann Dermatol. 2011;23(Suppl 2):S201-4.
Aggressive behavior
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 10

HPO ID Term # of case reports
HP:0030731 Carcinoma 15
HP:0002861 Melanoma 6
HP:0003002 Breast carcinoma 5
HP:0030075 Ductal carcinoma in situ 2
HP:0000964 Eczema 1
HP:0002664 Neoplasm 1
HP:0002860 Squamous cell carcinoma 1
HP:0012056 Cutaneous melanoma 1
HP:0012740 Papilloma 1
HP:0030076 Lobular carcinoma in situ 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID