Paget disease of the nipple

Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses.

Input patient's signs and symptoms

Narrow down the case reports

Total: 55 (papers)

(per page)

Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (4.0%)	21768603	Intraepidermal glandular carcinoma of the nipple (mammary Paget-like disease) in 2 dogs. Ramirez GA, Suarez-Bonnet A, Altimira J, Espinosa-de-los-Monteros A, Garcia-Gonzalez B, Vilafranca M. Vet Pathol. 2012;49(4):612-5. [ Show abstract ] [ Hide abstract ]
		Carcinoma


		Adenocarcinoma Animals Canis familiaris Dog Diseases Females Male Mammary Glands, Animal Paget's Disease, Mammary
1 (4.0%)	21738368	Pigmented mammary paget disease with reticulated features: a rare variant of mammary paget disease. Lee EA, Kim HS, Kim HO, Park YM. Ann Dermatol. 2011;23(1):73-5. [ Show abstract ] [ Hide abstract ]
		Carcinoma



1 (4.0%)	21587034	Pigmented paget disease of the breast nipple with underlying infiltrating carcinoma: a case report and review of the literature. Soler T, Lerin A, Serrano T, Masferrer E, Garcia-Tejedor A, Condom E. Am J Dermatopathol. 2011;33(5):e54-7. [ Show abstract ] [ Hide abstract ]
		Melanoma


		Females Homo sapiens Immunohistochemistry Middle Aged Nipples Paget's Disease, Mammary Pigmentation
1 (4.0%)	20803209 (3070876)	Treatment of recurrent vulvar Paget disease with imiquimod cream: a case report and review of the literature. Tonguc E, Gungor T, Var T, Ozat M, Sahin I, Sirvan L. Arch Gynecol Obstet. 2011;283(1):97-101. [ Show abstract ] [ Hide abstract ]
		Erythematous plaque


		Aminoquinolines Antineoplastic Agents Emollients Females Homo sapiens Neoplasm Recurrence, Local Paget Disease Extramammary Vulvar Neoplasms
1 (4.0%)	20432750	Misleading presentations of malignant breast diseases--role of clinical cytology. Kaic G, Stoos-Veic T, Ostovic KT, Vojnovic J, Vidovic L, Lambasa S, Harim V, Ajdukovic R, Stanec S, Budi S. Coll Antropol. 2010;34(1):193-5. [ Show abstract ] [ Hide abstract ]
		Breast carcinoma


		Cytodiagnosis Differential Diagnosis Diffuse Large B-Cell Lymphoma Females Homo sapiens Middle Aged Nipples Paget's Disease, Mammary Reproducibility of Results
1 (4.0%)	18950495 (2584629)	Mucinous breast carcinoma presenting as Paget's disease of the nipple in a man: a case report. Peschos D, Tsanou E, Dallas P, Charalabopoulos K, Kanaris C, Batistatou A. Diagn Pathol. 2008;3:42. [ Show abstract ] [ Hide abstract ]
		Breast carcinoma



1 (4.0%)	18417683	Cystic hypersecretory carcinoma of the breast with paget disease of the nipple: a diagnostic challenge. Sahoo S, Gopal P, Roland L, Pile N. Int J Surg Pathol. 2008;16(2):208-12. [ Show abstract ] [ Hide abstract ]
		Carcinoma


		Carcinoma in Situ Females Homo sapiens Mastectomy Middle Aged Nipples Paget's Disease, Mammary Ultrasonography, Mammary
1 (4.0%)	18171616	Bilateral Paget disease of the male nipple: first report. Ucar AE, Korukluoglu B, Ergul E, Aydin R, Kusdemir A. Breast. 2008;17(3):317-8. [ Show abstract ] [ Hide abstract ]
		Carcinoma


		Breast Neoplasms, Male Homo sapiens Male Mammography Mastectomy Neoplasms, Multiple Primary Nipples Paget's Disease, Mammary
1 (4.0%)	17576941	Pigmented mammary Paget disease: dermoscopic, in vivo reflectance-mode confocal microscopic, and immunohistochemical study of a case. Longo C, Fantini F, Cesinaro AM, Bassoli S, Seidenari S, Pellacani G. Arch Dermatol. 2007;143(6):752-4. [ Show abstract ] [ Hide abstract ]
		Melanoma


		Dermoscopy Differential Diagnosis Females Homo sapiens Hyperpigmentation Immunohistochemistry Microscopy, Confocal Paget's Disease, Mammary Skin Neoplasms
1 (4.0%)	17083907	Surrounding ipsilateral eruptive seborrheic keratosis as a warning sign of intraductal breast carcinoma and Paget's disease (Leser Trelat sign). Shamsadini S, Wadji MB, Shamsadini A. Dermatol Online J. 2006;12(6):27. [ Show abstract ] [ Hide abstract ]
		Breast carcinoma


		Breast Diseases Females Homo sapiens Middle Aged Nipples Noninfiltrating Intraductal Carcinoma Paget's Disease, Mammary Paraneoplastic Syndromes

Phenotype(s) retrieved from Orphanet

Total: 0

HPO ID	Term	Frequency

Phenotype(s) retrieved from case reports

Total: 10

HPO ID	Term	# of case reports
HP:0030731	Carcinoma	15
HP:0002861	Melanoma	6
HP:0003002	Breast carcinoma	5
HP:0030075	Ductal carcinoma in situ	2
HP:0000964	Eczema	1
HP:0002664	Neoplasm	1
HP:0002860	Squamous cell carcinoma	1
HP:0012056	Cutaneous melanoma	1
HP:0012740	Papilloma	1
HP:0030076	Lobular carcinoma in situ	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID