Immune-mediated necrotizing myopathy

Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation.



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Narrow down the case reports



Total: 24 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(27.3%)
28717093
(5548690)
Paraneoplastic Anti-3-hydroxy-3-methylglutary-coenzyme A Reductase Antibody-positive Immune-mediated Necrotizing Myopathy in a Patient with Uterine Cancer.
Mizuma A, Kouchi M, Netsu S, Yutani S, Kitao R, Suzuki S, Murata K, Nagata E, Takizawa S.
Intern Med. 2017;56(14):1915-1918.
Myopathy Limb muscle weakness
HMGCR
Autoantibodies Autoimmune Diseases Biopsy Females Homo sapiens Myopathy Necrosis Signal Recognition Particle Uterine Neoplasms
2
(23.3%)
22453528
Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku.
Zenone T, Streichenberger N, Puget M.
Rheumatol Int. 2013;33(9):2411-5.
Rhabdomyolysis Camptocormia
Antigens, Nuclear Autoantibodies DNA-Binding Proteins Homo sapiens Male Polymyositis Spinal Muscular Atrophy Systemic Scleroderma
3
(17.5%)
31020206
Statin-induced myopathy: a case report.
De Cock E, Hannon H, Moerman V, Schurgers M.
Eur Heart J Case Rep. 2018;2(4):yty130.
Muscle weakness
HMGCR
3
(17.5%)
30788073
Anti-HMG-CoA reductase myopathy, an undesirable evolution of statin induced myopathy: a case report.
Upreti S, Fayyaz B, Bongu RP.
J Community Hosp Intern Med Perspect. 2019;9(1):33-35.
Muscle weakness
HMGCR
3
(17.5%)
30464165
Necrotizing Autoimmune myopathy: A case report on statin induced rhabdomyolysis requiring immunosuppressive therapy.
Kunwar S, Parekh JD, Chilukuri RS, Andukuri VA.
Drug Discov Ther. 2018;12(5):315-317.
Muscle weakness
Autoantibodies Autoimmune Diseases Creatine Kinase Females Homo sapiens Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunosuppressive Agents Middle Aged Myositis Rhabdomyolysis
3
(17.5%)
29995816
(6076171)
Anti-NXP2-antibody-positive immune-mediated necrotizing myopathy associated with acute myeloid leukemia: A case report.
Su L, Yang Y, Jia Y, Liu X, Zhang W, Yuan Y, Li Z.
Medicine (Baltimore). 2018;97(28):e11501.
Muscle weakness
MORC3
Adenosine Triphosphatases DNA-Binding Proteins Females Glucocorticoids Homo sapiens Leukemia, Myelocytic, Acute Myositis
3
(17.5%)
29794576
Case of Anti-Single Recognition Particle-Mediated Necrotizing Myopathy After Influenza Vaccination.
Mamarabadi M, Baisre A, Leitch M, Hsu V, Kanduri JS, Chen S.
J Clin Neuromuscul Dis. 2018;19(4):211-216.
Muscle weakness
KRT20
Adult Creatine Kinase Females Homo sapiens Immunologic Factors Magnetic Resonance Imaging Methylprednisolone Hemisuccinate Myopathy Neuroprotective Agents Reaction Time
3
(17.5%)
28066895
Anti-3-hydroxy-3-methylglutaryl-coenzyme a reductase necrotizing myopathy masquerading as a muscular dystrophy in a child.
Mohassel P, Foley AR, Donkervoort S, Fequiere PR, Pak K, Bonnemann CG, Mammen AL.
Muscle Nerve. 2017;56(6):1177-1181.
Necrotizing myopathy
HMGCR
Autoantibodies Differential Diagnosis Homo sapiens Male Muscular Dystrophy Myopathy Necrosis
3
(17.5%)
27922497
Autoimmune Myopathies.
Mammen AL.
Continuum (Minneap Minn). 2016;22(6, Muscle and Neuromuscular Junction Disorders):1852-1870.
Myopathy
Autoantibodies Autoimmune Diseases Dermatomyositis Electromyography Females Homo sapiens Male Middle Aged Myopathy Myositis
3
(17.5%)
27795789
(5072849)
Polymyositis anti-SRP antibodies and pregnancy about 2 cases.
Ousmane C, Makhtar BE, Fatoumata B, Massi GD, Lemine DS, Soda DM, Dieynaba SA, Anna B, Bouna SL, Moustapha N, Gallo DA, Mansour NM.
Pan Afr Med J. 2016;24:192.
Myopathy
Adult Antibodies Females Homo sapiens Polymyositis Postpartum Period Pregnancy Pregnancy Complications Signal Recognition Particle
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 8

HPO ID Term # of case reports
HP:0003198 Myopathy 4
HP:0100614 Myositis 2
HP:0000969 Edema 1
HP:0002015 Dysphagia 1
HP:0003201 Rhabdomyolysis 1
HP:0003701 Proximal muscle weakness 1
HP:0009071 Inflammatory myopathy 1
HP:0012115 Hepatitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID