Immune-mediated necrotizing myopathy

Necrotizing autoimmune myopathy (NAM) is a rare form of idiopathic inflammatory myopathy characterized clinically by acute or subacute proximal muscle weakness, and histopathologically by myocyte necrosis and regeneration without significant inflammation.



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Total: 24 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
3
(17.5%)
19813188
Immune-mediated necrotizing myopathy associated with statins.
Grable-Esposito P, Katzberg HD, Greenberg SA, Srinivasan J, Katz J, Amato AA.
Muscle Nerve. 2010;41(2):185-90.
Elevated serum creatine kinase Proximal muscle weakness
Aged, 80 and over Biopsy Creatine Kinase Females Homo sapiens Hydroxymethylglutaryl-CoA Reductase Inhibitors Immunosuppressive Agents Immunotherapy Male Middle Aged Muscle Weakness Myopathy Necrosis Retrospective Studies Withholding Treatment
3
(17.5%)
18344715
Steroid-responsive myopathy: immune-mediated necrotizing myopathy or polymyositis without inflammation?
Sadeh M, Dabby R.
J Clin Neuromuscul Dis. 2008;9(3):341-4.
Necrotizing myopathy
Creatine Kinase Homo sapiens Male Myopathy Necrosis Severity of Illness Index Steroids
3
(17.5%)
12235311
Myopathy with antibodies to the signal recognition particle: clinical and pathological features.
Miller T, Al-Lozi MT, Lopate G, Pestronk A.
J Neurol Neurosurg Psychiatry. 2002;73(4):420-8.
Myopathy
Adult Anti-Inflammatory Agents Antibodies, Anti-Idiotypic Biopsy Creatine Kinase Females Homo sapiens Male Middle Aged Myositis Signal Recognition Particle Steroids
24
(4.0%)
27190496
(4869331)
A case report of autoimmune necrotizing myositis presenting as dysphagia and neck swelling.
Ngo LQ, Wu AG, Nguyen MA, McPherson LE, Gertner E.
BMC Ear Nose Throat Disord. 2016;16:7.
Dysphagia
HMGCR
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 8

HPO ID Term # of case reports
HP:0003198 Myopathy 4
HP:0100614 Myositis 2
HP:0000969 Edema 1
HP:0002015 Dysphagia 1
HP:0003201 Rhabdomyolysis 1
HP:0003701 Proximal muscle weakness 1
HP:0009071 Inflammatory myopathy 1
HP:0012115 Hepatitis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID