Carcinosarcoma of the corpus uteri

Carcinosarcoma of the corpus uteri is a rare, malignant, mixed epithelial and mesenchymal tumor of the uterine body composed of high-grade carcinomatous and sarcomatous elements. It may present with vaginal bleeding, abnormal vaginal discharge, abdominal pain and/or pelvic mass, with a polypoid tumor sometimes protruding through the cervical canal. Association with Tamoxifen therapy, long-term unopposed estrogen use and previous pelvic radiotherapy has been reported.



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Total: 46 (papers)

   


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Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
2
(4.0%)		 22188664
(3259127)
 Cervical adenocarcinoma presenting as a cardiac tamponade in a 57-year-old woman: a case report.
Azria E, Dufeu M, Fernandez P, Walker F, Luton D.
J Med Case Rep. 2011;5:594.
Pericardial effusion
2
(4.0%)		 21769295
(3134036)
 Carcinosarcoma of the uterine corpus with alpha-fetoprotein-producing hepatoid adenocarcinoma: a report of two cases.
Kawaguchi R, Furukawa N, Yamada Y, Ooi H, Kobayashi H.
Case Rep Oncol. 2011;4(2):358-62.
Sarcoma
AFP
2
(4.0%)		 20890074
 Carcinosarcoma of the uterus in a woman with Down syndrome.
Al-Badawi IA, AlOmar O, Kornfeld I.
Hematol Oncol Stem Cell Ther. 2010;3(3):161-2.
Neoplasm
Adult Carcinosarcoma Differential Diagnosis Down Syndrome Females Homo sapiens Uterine Neoplasms
2
(4.0%)		 20524448
 Carcinosarcoma arising in uterine didelphys after tamoxifen therapy for breast cancer: a case report.
Suprasert P, Khunamornpong S.
J Med Assoc Thai. 2010;93(5):608-12.
Pelvic mass
Antineoplastic Agents, Hormonal Carcinosarcoma Chemotherapy, Adjuvant Fatal Outcome Females Homo sapiens Mastectomy Postmenopause Uterine Neoplasms
2
(4.0%)		 20198774
 [Uterine carcinosarcoma with chondroid differentiation--immuhistochemical examination].
Porjazova E, Zaprjanov Z, Batashki I, Markova D, Milchev N.
Akush Ginekol (Sofiia). 2009;48(2):26-8.
Uterine neoplasm
S100A1 VIM
Carcinosarcoma Cytokeratin Females Homo sapiens Immunohistochemistry S100 Proteins Uterine Neoplasms Uterus Vimentin
2
(4.0%)		 19111933
 Uterine carcinosarcoma metastatic to the lung as large-cell neuroendocrine carcinoma with synchronous sarcoid granulomatosis.
Froio E, D'Adda T, Fellegara G, Martella E, Caruana P, Pruneri G, Pesci A, Rindi G.
Lung Cancer. 2009;64(3):371-7.
Lymphadenopathy
Carcinoma, Neuroendocrine Carcinosarcoma Fallopian Tubes Females Homo sapiens Hysterectomy Lung Neoplasms Middle Aged Ovariectomy Positron-Emission Tomography Sarcoidosis Segmental Mastectomy Uterine Neoplasms X-Ray Computed Tomography
2
(4.0%)		 19051829
 Carcinosarcoma of the uterus: a case report and review of the literature.
Spaziani E, Picchio M, Petrozza V, Briganti M, Ceci F, Di Filippo A, Sardella B, De Angelis F, Della Rocca C, Stagnitti F.
Eur J Gynaecol Oncol. 2008;29(5):531-4.
Anemia
Aged, 80 and over Carcinosarcoma Females Homo sapiens Uterine Neoplasms
2
(4.0%)		 18834571
 [A case of uterine carcinosarcoma].
Spaziani E, Picchio M, Di Filippo A, Petrozza V, Censi F, Sardella B, Briganti M, Ceci F, Nicodemi S, Nardecchia G, De Angelis F, Cipriani B, Stagnitti F.
G Chir. 2008;29(8-9):365-8.
Hypertension
Aged, 80 and over Carcinosarcoma Females Homo sapiens Uterine Neoplasms
2
(4.0%)		 18548260
 Malignant pericardial effusion and cardiac tamponade originating from uterine carcinosarcoma.
Shimizu S, Yajima M, Yoshii A, Nishikawa T, Ohta H.
Arch Gynecol Obstet. 2009;279(3):373-5.
Pericardial effusion
Carcinosarcoma Cardiac Tamponade Fatal Outcome Females Homo sapiens Middle Aged Uterine Neoplasms
2
(4.0%)		 18501546
 Carcinosarcoma of the uterus: radiologic-pathologic correlations with magnetic resonance imaging including diffusion-weighted imaging.
Kato H, Kanematsu M, Furui T, Imai A, Hirose Y, Kondo H, Goshima S, Tsuge Y.
Magn Reson Imaging. 2008;26(10):1446-50.
Sarcoma
Carcinosarcoma Contrast Media Diffusion Magnetic Resonance Imaging Fatal Outcome Females Gadolinium DTPA Homo sapiens Magnetic Resonance Imaging Middle Aged Necrosis Postmenopause Uterine Neoplasms
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 11

HPO ID Term # of case reports
HP:0030731 Carcinoma 7
HP:0100242 Sarcoma 3
HP:0001903 Anemia 2
HP:0000718 Aggressive behavior 1
HP:0001548 Overgrowth 1
HP:0001698 Pericardial effusion 1
HP:0002664 Neoplasm 1
HP:0002835 Aspiration 1
HP:0002860 Squamous cell carcinoma 1
HP:0003003 Colon cancer 1
HP:0012114 Endometrial carcinoma 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID