Acute myeloblastic leukemia without maturation

A rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.



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Narrow down the case reports



Total: 49 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(23.3%)
20068278
[Pyogenic spondylitis following unrelated hematopoietic stem cell transplantation].
Mukaiyama Y, Hashino S, Onozawa M, Okada K, Takahata M, Kahata K, Asaka M.
Rinsho Ketsueki. 2009;50(12):1706-10.
Diabetes mellitus Back pain
Anti-Bacterial Agents Back Pain Differential Diagnosis Females Homo sapiens Immunocompromised Host Leukemia, Myelocytic, Acute Magnetic Resonance Imaging Middle Aged Spondylitis Suppuration Thienamycins Time Factors Transplantation, Homologous
2
(21.2%)
8587173
[Acute myeloid leukemia (M1) following chemotherapy for Ki-1 lymphoma complicated with rheumatoid arthritis].
Yoshida K, Endoh K, Itoh Y, Kawai N, Matsuda A, Murohashi I, Jinnai I, Ino H, Bessho M, Takeuchi H, et al..
Rinsho Ketsueki. 1995;36(12):1365-71.
Rheumatoid arthritis
ANPEP DDIT3 HCFC1 KMT2A TNFRSF8
Antineoplastic Combined Chemotherapy Protocols Females Homo sapiens Leukemia, Myelocytic, Acute Middle Aged Neoplasms, Second Primary Rheumatoid Arthritis
3
(4.0%)
29563973
(5851247)
Down syndrome associated childhood myeloid leukemia with yet unreported acquired chromosomal abnormalities and a new potential adverse marker: dup(1)(q25q44).
Moassass F, Wafa A, Liehr T, Al-Ablog A, Al Achkar W.
Mol Cytogenet. 2018;11:22.
Myeloid leukemia
3
(4.0%)
29264902
A transient cutaneous relapse of AML M1 in hematological remission: a case report.
di Meo N, Pozzato G, Leonardo E, Trevisini S, Vichi S, Trevisan G.
Acta Dermatovenerol Alp Pannonica Adriat. 2017;26(4):109-111.
Leukemia
Females Homo sapiens Leukemia, Myelocytic, Acute Leukemic Infiltration Skin Skin Neoplasms
3
(4.0%)
25492662
[An unusual cause of febrile neutropenia: brucellosis].
Solmaz S, Asma S, Ozdogu H, Yeral M, Turunc T.
Mikrobiyol Bul. 2014;48(4):669-73.
Petechiae
Brucellosis Fatal Outcome Febrile Neutropenia Fever Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged Septic Shock
3
(4.0%)
24124438
(3793386)
Identification of homogeneously staining regions in leukemia patients.
Moghadam MH, Movafagh A, Omrani M, Ghanati K, Hashemi M, Poursafavi F, Darvish H, Abdolahi DZ, Gholami M, Heidari Rostamy MR, Safari S, Haghnejad L, Darehgazani R, Naeini NS, Motlagh MG, Amani D.
J Res Med Sci. 2013;18(4):363-5.
Leukemia
3
(4.0%)
22747755
(4501036)
Acute myeloblastic leukemia with associated BCR-ABL translocation in a dog.
Figueiredo JF, Culver S, Behling-Kelly E, Breen M, Friedrichs KR.
Vet Clin Pathol. 2012;41(3):362-368.
Thrombocytopenia
Animals Bone Marrow Canis familiaris Cytogenetic Analysis Dog Diseases Fluorescent in Situ Hybridization Fusion Proteins, bcr-abl Hematologic Tests Immunophenotyping Leukemia, Myelocytic, Acute Male
3
(4.0%)
22423656
[Conjunctival myeloid sarcoma in acute myeloblastic leukemia-M1].
Mendez-Cepeda P, Millan-Rodriguez AC, Dios E, Alvarez C, Sevillano C.
Arch Soc Esp Oftalmol. 2012;87(3):79-81.
Leukemia
Antineoplastic Combined Chemotherapy Protocols Biopsy Fatal Outcome Homo sapiens Leukemia, Myelocytic, Acute Leukemic Infiltration Male Multiple Organ Failure Sarcoma, Myeloid Skin
3
(4.0%)
19027489
Jumping translocations in hematological malignancies: a cytogenetic study of five cases.
Manola KN, Georgakakos VN, Stavropoulou C, Spyridonidis A, Angelopoulou MK, Vlachadami I, Katsigiannis A, Roussou P, Pantelias GE, Sambani C.
Cancer Genet Cytogenet. 2008;187(2):85-94.
Leukemia
KMT2A
Adult Burkitt Lymphoma Cytogenetic Analysis Females Hematologic Neoplasms Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged Precursor Cell Lymphoblastic Leukemia Lymphoma Young Adult
3
(4.0%)
18094565
[Hematologic and clinical features of 3q21q26 syndrome: extremely poor prognosis and association with central diabetes insipidus].
Chung HJ, Seo EJ, Kim KH, Jang S, Park CJ, Chi HS, Lee JH, Lee JH, Lee KH.
Korean J Lab Med. 2007;27(2):133-8.
Diabetes insipidus
CD7 NCAM1 RPN1
Adult Central Diabetes Insipidus Chromosomes, Human, Pair 3 Females Hematologic Neoplasms Homo sapiens Male Middle Aged Monosomy Syndrome
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 11

HPO ID Term # of case reports
HP:0001909 Leukemia 5
HP:0001945 Fever 3
HP:0001664 Torsade de pointes 1
HP:0001873 Thrombocytopenia 1
HP:0001875 Neutropenia 1
HP:0001880 Eosinophilia 1
HP:0001907 Thromboembolism 1
HP:0001974 Leukocytosis 1
HP:0002090 Pneumonia 1
HP:0011675 Arrhythmia 1
HP:0032169 Severe infection 1


Causative gene(s) retrieved from Orphanet

    Total: 2

Gene Symbol Gene Name Entrez Gene ID
FLT3 fms related tyrosine kinase 3 2322
NPM1 nucleophosmin 1 4869