Acute myeloblastic leukemia without maturation

A rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.



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Total: 49 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
3
(4.0%)
8366573
[Refractory bilateral pneumothoraces complicated with interstitial pneumonitis after bone marrow transplantation].
Hoshino Y, Hatake K, Mimuro J, Nakamura Y, Ashizawa N, Tsunoda S, Muroi K, Suda T, Yoshida M, Miwa A, et al..
Rinsho Ketsueki. 1993;34(6):718-22.
Pneumonia
ABO
Adult Bone Marrow Transplantation Cranial Irradiation Drug Administration Schedule Homo sapiens Leukemia, Myelocytic, Acute Male Pneumothorax Pulmonary Fibrosis
3
(4.0%)
8194050
Trisomy 19 as the sole chromosomal anomaly in hematologic neoplasms.
Johansson B, Billstrom R, Mauritzson N, Mitelman F.
Cancer Genet Cytogenet. 1994;74(1):62-5.
Neoplasm
Acute Disease Chromosomes, Human, Pair 19 Females Homo sapiens Leukemia, Myelomonocytic, Chronic Male Middle Aged Myeloid Leukemia Trisomy
3
(4.0%)
8174079
Acute myeloid leukemia (AML-M1) with multiple trisomies and t(8;21)(q22;q22).
Kohler M, Johansson B, Ludvigsson J, Aman P, Heim S, Mitelman F.
Cancer Genet Cytogenet. 1994;73(1):79-81.
Leukemia
Child Chromosomes, Human, Pair 21 Chromosomes, Human, Pair 8 Diploidy Homo sapiens Leukemia, Myelocytic, Acute Male Trisomy Tumor Cells, Cultured
3
(4.0%)
7827204
Secondary acute myeloid leukemia with translocation (4;11) and MLL/AF4 rearrangement in a 15-year-old boy treated for common acute lymphoblastic leukemia 11 years earlier.
Blutters-Sawatzki R, Borkhardt A, Grathwohl J, Repp R, Rheinisch-Becker I, Bohle RM, Lampert F.
Ann Hematol. 1995;70(1):31-5.
Thrombocytopenia
AFF1 FANCB KMT2A
Acute Disease Bone Marrow Bone Marrow Transplantation Chromosomes, Human, Pair 11 Chromosomes, Human, Pair 4 DNA, Neoplasm DNA-Binding Proteins Gene Rearrangement Histone-Lysine N-Methyltransferase Homo sapiens Male Myeloid Leukemia Myeloid-Lymphoid Leukemia Protein Nuclear Proteins Polymerase Chain Reaction Precursor Cell Lymphoblastic Leukemia Lymphoma Proto-Oncogenes RNA, Messenger Transcriptional Elongation Factors Transplantation, Homologous
3
(4.0%)
7686236
[Acute mixed lineage leukemia showing resistance to AML and ALL therapy].
Kawashima H, Iizuka Y, Kondou W, Hirota H, Okuyama Y, Kanou M, Ichii S, Murakami J, Tsuchiya T, Sawada T, et al..
Rinsho Ketsueki. 1993;34(5):643-8.
Leukemia
Antigens, Differentiation, B-Lymphocyte Antigens, Differentiation, Myelomonocytic Antineoplastic Combined Chemotherapy Protocols B-Lymphocytes CD Antigens CD19 Antigens Females Homo sapiens Leukemia, Myelocytic, Acute Middle Aged Precursor Cell Lymphoblastic Leukemia Lymphoma
3
(4.0%)
2020123
[Successful pregnancy after 6 years complete remission in patient with acute myeloblastic leukemia].
Shimazaki C, Oku N, Gotoh H, Inaba T, Murakami S, Oku N, Itoh K, Nakanishi S, Nakagawa M, Fujita N.
Rinsho Ketsueki. 1991;32(1):71-2.
Leukemia
Adult Antineoplastic Combined Chemotherapy Protocols Females Homo sapiens Leukemia, Myelocytic, Acute Pregnancy Remission Induction
3
(4.0%)
1942537
[Torsade de pointes ventricular tachycardia in a patient with acute myelocytic leukemia].
Morioka M, Kakinoki Y, Katagiri M, Iwasaki H, Gotohda Y, Kobayashi T, Tanaka M, Sakurada K, Miyazaki T.
Rinsho Ketsueki. 1991;32(9):1009-11.
Cardiomyopathy
Adult Antineoplastic Combined Chemotherapy Protocols Electrocardiography Females Homo sapiens Leukemia, Myelocytic, Acute Tachycardia
3
(4.0%)
1479694
[der(1;7) (q10;p10) in three patients with malignant hematologic disorders].
Yokoo H, Okada Y, Tominaga K, Tsuji M, Takagi T, Maseki N, Sakurai M, Kaneko Y.
Rinsho Ketsueki. 1992;33(12):1829-33.
Leukemia
Adult Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 7 Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged
3
(4.0%)
1402119
[A case of tracho-bronchial aspergillosis complicated with acute myeloblastic leukemia].
Saburi Y, Tashiro T, Ishii T, Miyazaki S, Masuda M, Mieno T, Moriuchi A, Kikuchi H, Nasu M.
Kansenshogaku Zasshi. 1992;66(8):1120-4.
Thrombocytopenia
Aspergillosis Bronchial Diseases Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged Tracheal Diseases
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 11

HPO ID Term # of case reports
HP:0001909 Leukemia 5
HP:0001945 Fever 3
HP:0001664 Torsade de pointes 1
HP:0001873 Thrombocytopenia 1
HP:0001875 Neutropenia 1
HP:0001880 Eosinophilia 1
HP:0001907 Thromboembolism 1
HP:0001974 Leukocytosis 1
HP:0002090 Pneumonia 1
HP:0011675 Arrhythmia 1
HP:0032169 Severe infection 1


Causative gene(s) retrieved from Orphanet

    Total: 2

Gene Symbol Gene Name Entrez Gene ID
FLT3 fms related tyrosine kinase 3 2322
NPM1 nucleophosmin 1 4869