Acute myeloblastic leukemia without maturation

A rare, acute myeloid leukemia characterized by no significant myeloid maturation and more than 90% blast cells in the non-erythroid population. Various degrees of anemia, thrombocytopenia, or pancytopenia are present. Frequent clinical manifestations include fatigue, fever, bleeding disorders, and organomegaly, especially hepatosplenomegaly.



Input patient's signs and symptoms


Narrow down the case reports



Total: 49 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
3
(4.0%)
12127406
Tetrasomy 13 as the sole cytogenetic abnormality in acute myeloid leukemia M1 without maturation.
McGrattan P, Alexander HD, Humphreys MW, Kettle PJ.
Cancer Genet Cytogenet. 2002;135(2):192-5.
Anemia
SLC6A3
Aneuploidy Antineoplastic Combined Chemotherapy Protocols Chromosomes, Human, Pair 13 Drug Resistance, Neoplasm Fatal Outcome Granulocyte Colony-Stimulating Factor Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged
3
(4.0%)
12096491
[Granulocytic sarcoma developing in lymph nodes].
Watanabe I, Yakushijin Y, Sakai I, Yasukawa M, Fujita S.
Rinsho Ketsueki. 2002;43(5):378-83.
Leukemia
ACE ITGAM MPO MT1IP SPN
Antineoplastic Combined Chemotherapy Protocols Diffuse Large B-Cell Lymphoma Homo sapiens Leukemia, Myelocytic, Acute Male Neoplasms, Second Primary Sarcoma, Myeloid
3
(4.0%)
11734321
Deletion of 16q11 is a recurrent cytogenetic aberration in acute myeloblastic leukemia during disease progression.
Yamamoto K, Nagata K, Kida A, Hamaguchi H.
Cancer Genet Cytogenet. 2001;131(1):65-8.
Leukemia
ANPEP CD33 CD34
Child Chromosome Banding Chromosome Deletion Chromosomes, Human, Pair 16 Disease Progression Fatal Outcome Females Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged
3
(4.0%)
11529469
Spontaneous remission in a secondary acute myelogenous leukaemia following invasive pulmonary aspergillosis.
Tzankov A, Ludescher C, Duba HC, Steinlechner M, Knapp R, Schmid T, Grunewald K, Gastl G, Stauder R.
Ann Hematol. 2001;80(7):423-5.
Chronic hepatitis
CSF3
Aspergillosis Bone Marrow Females Homo sapiens Leukemia, Myelocytic, Acute Lung Lung Diseases, Fungal Middle Aged Remission, Spontaneous X-Ray Computed Tomography
3
(4.0%)
11400303
[CD13- and CD33-negative acute myelocytic leukemia (FAB classification; M2) with morphological changes and CD13 expression on recurrence].
Aoyama Y, Yamane T, Kanashima H, Takeoka Y, Koh K, Nakao Y, Yamamura R, Nakamae H, Ohta K, Inoue T, Hino M, Tatsumi N.
Rinsho Ketsueki. 2001;42(4):314-20.
Leukemia
ANPEP CD33
Adult Antigens, Differentiation, Myelomonocytic Bone Marrow Transplantation CD Antigens Flow Cytometry Homo sapiens Leukemia, Myelocytic, Acute Male Phenotype
3
(4.0%)
11393347
Treatment of acute myeloblastic leukaemia in a patient with Bombay blood type: a case report.
Okamoto Y, Tsuda T, Matsunami M, Hirose T, Sakaguchi R, Katayama N, Ota K.
J Int Med Res. 2001;29(2):140-6.
Pneumonia
Antineoplastic Agents Blood Group Antigens Females Homo sapiens Leukemia, Myelocytic, Acute Male Middle Aged Phenotype
3
(4.0%)
11280924
[Therapy-related myeloid leukemia following platinum-based chemotherapy for ovarian cancer].
Shimura K, Shimazaki C, Okano A, Hatsuse M, Okamoto A, Takahashi R, Hirai H, Sumikuma T, Ashihara E, Inaba T, Fujita N, Yasuda J, Nakagawa M.
Rinsho Ketsueki. 2001;42(2):99-103.
Pancytopenia
CD33 ITGAX NCAM1
Adult Antineoplastic Combined Chemotherapy Protocols Females Homo sapiens Myeloid Leukemia Neoplasms, Second Primary
3
(4.0%)
10942805
Trisomy 10 in acute myeloid leukemia. Three additional cases from the database of the Japan Adult Leukemia Study Group (JALSG) AML-92 and AML-95.
Suzuki A, Kimura Y, Ohyashiki K, Kitano K, Kageyama S, Kasai M, Miyawaki S, Ohno R.
Cancer Genet Cytogenet. 2000;120(2):141-3.
Cerebral hemorrhage
CD7
Adult Aged, 80 and over CD7 Antigens Chromosomes, Human, Pair 10 Databases as Topic Fatal Outcome Females Homo sapiens Japan Leukemia, Myelocytic, Acute Male Middle Aged Trisomy
3
(4.0%)
10785268
A novel translocation t(3;22)(q21;q11) involving 3q21 in myelodysplastic syndrome-derived overt leukemia with thrombocytosis.
Yamamoto K, Nagata K, Tsurukubo Y, Morishita K, Hamaguchi H.
Leuk Res. 2000;24(5):453-7.
Thrombocytosis
Adult Child Chromosomes, Human, Pair 22 Chromosomes, Human, Pair 3 Females Homo sapiens Infant Leukemia, Myelocytic, Acute Male Middle Aged Thrombocytosis
3
(4.0%)
10342585
Differentiation of leukemic cells induced by short-course high-dose methylprednisolone in children with different subtypes of acute myeloblastic leukemia.
Hicsonmez G, Tuncer M, Toksoy HB, Yenicesu I, Cetin M.
Leuk Lymphoma. 1999;33(5-6):573-80.
Leukemia
Administration, Oral Anti-Inflammatory Agents Females Homo sapiens Leukemia, Myelocytic, Acute
        

Phenotype(s) retrieved from Orphanet

    Total: 0

HPO ID Term Frequency


Phenotype(s) retrieved from case reports

    Total: 11

HPO ID Term # of case reports
HP:0001909 Leukemia 5
HP:0001945 Fever 3
HP:0001664 Torsade de pointes 1
HP:0001873 Thrombocytopenia 1
HP:0001875 Neutropenia 1
HP:0001880 Eosinophilia 1
HP:0001907 Thromboembolism 1
HP:0001974 Leukocytosis 1
HP:0002090 Pneumonia 1
HP:0011675 Arrhythmia 1
HP:0032169 Severe infection 1


Causative gene(s) retrieved from Orphanet

    Total: 2

Gene Symbol Gene Name Entrez Gene ID
FLT3 fms related tyrosine kinase 3 2322
NPM1 nucleophosmin 1 4869