Dermatitis herpetiformis

A chronic autoimmune subepidermal bullous disease characterized by grouped pruritic lesions such as papules, urticarial plaques, erythema, and herpetiform vesiculae, with a predominantly symmetrical distribution on extensor surfaces of the elbows (90%), knees (30%), shoulders, buttocks, sacral region, and face of children and adults. Erosions, excoriations and hyperpigmentation usually follow. It may also appear as a consequence of gluten intolerance.



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Narrow down the case reports



Total: 163 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
10
(37.5%)		 22379467
(3290019)
 Untreated celiac disease in a patient with dermatitis herpetiformis leading to a small bowel carcinoma.
Derikx MH, Bisseling TM.
Case Rep Gastroenterol. 2012;6(1):20-5.
Weight loss Anemia Vomiting
12
(36.6%)		 21848992
 Dermatitis herpetiformis presenting as digital petechiae.
Heinlin J, Knoppke B, Kohl E, Landthaler M, Karrer S.
Pediatr Dermatol. 2012;29(2):209-12.
Scotoma Petechiae Recurrent tonsillitis
Celiac Disease Dermatitis Herpetiformis Females Fingers Folic Acid Antagonists Gluten-Free Diet Homo sapiens Purpura
13
(33.4%)		 22068782
 Bullous systemic lupus erythematosus: differential diagnosis with dermatitis herpetiformis.
Barbosa WS, Rodarte CM, Guerra JG, Maciel VG, Fleury Junior LF, Costa MB.
An Bras Dermatol. 2011;86(4 Suppl 1):S92-5.
Anemia Pyuria
Child Dermatitis Herpetiformis Differential Diagnosis Females Homo sapiens Lupus Erythematosus, Systemic Skin Diseases, Vesiculobullous
14
(32.0%)		 29492350
(5820012)
 Scabies Surrepticius: Scabies Masquerading as Pityriasis Rosea.
Stiff KM, Cohen PR.
Cureus. 2017;9(12):e1961.
Urticaria Ecchymosis
14
(32.0%)		 23970137
 Acral purpura as leading clinical manifestation of dermatitis herpetiformis: report of two adult cases with a review of the literature.
Tu H, Parmentier L, Stieger M, Spanou Z, Horn M, Beltraminelli H, Borradori L.
Dermatology. 2013;227(1):1-4.
Petechiae
Adult Autoantibodies Biopsy Celiac Disease Dermatitis Herpetiformis Fingers GTP-Binding Proteins Gliadin Gluten-Free Diet Homo sapiens Male Middle Aged Protein Glutamine gamma Glutamyltransferase 2 Purpura Skin Transglutaminases
14
(32.0%)		 12403313
 Palmar petechiae in dermatitis herpetiformis: a case report and clinical review.
McCleskey PE, Erickson QL, David-Bajar KM, Elston DM.
Cutis. 2002;70(4):217-23.
Petechiae
Anti-Infective Agents Dermatitis Herpetiformis Differential Diagnosis Fluorescent Antibody Technique, Direct Hand Dermatoses Homo sapiens Male Middle Aged Purpura
14
(32.0%)		 6881854
 [Pseudopurpuric palmar localizations of herpetiform dermatitis].
Moulin G, Barrut D, Franc MP, Viornery P, Knezynski S.
Ann Dermatol Venereol. 1983;110(2):121-6.
Purpura
Adult Dermatitis Herpetiformis Differential Diagnosis Females Fingers Hand Dermatoses Homo sapiens Male Purpura
14
(32.0%)		 1035384
 [Herpetiforme pemphigus].
Jonquieres ED, Bonafina OA.
Med Cutan Ibero Lat Am. 1976;4(4):265-70.
Eosinophilia Erythema
Biopsy Dermatitis Herpetiformis Females Homo sapiens Middle Aged Pemphigus Skin
19
(27.8%)		 7960758
 [Angioimmunoblastic lymphadenopathy accompanied by Duhring disease-like lesions ].
Zumdick M, Megahed M, Borchard F, Wohde D, Goerz G.
Hautarzt. 1994;45(8):562-5.
Splenomegaly
Angioimmunoblastic Lymphadenopathy Biopsy Dermatitis Herpetiformis Differential Diagnosis Females Homo sapiens Lymphoma, T-Cell, Cutaneous Middle Aged Skin Skin Neoplasms
19
(27.8%)		 2780467
 Hypersplenism due to fungal infection of spleen in a successfully treated patient with Hodgkin's disease.
Raina V, Young PT, Foulis AK, Soukop M.
Postgrad Med J. 1989;65(760):83-5.
Splenomegaly
Antineoplastic Combined Chemotherapy Protocols Candidiasis Females Hodgkin Disease Homo sapiens Hypersplenism Middle Aged Splenectomy Splenic Diseases
        

Phenotype(s) retrieved from Orphanet

    Total: 14

HPO ID Term Frequency
HP:0000989 Pruritus Very frequent (99-80%)
HP:0001025 Urticaria Very frequent (99-80%)
HP:0001935 Microcytic anemia Very frequent (99-80%)
HP:0002024 Malabsorption Very frequent (99-80%)
HP:0002757 Recurrent fractures Very frequent (99-80%)
HP:0002960 Autoimmunity Very frequent (99-80%)
HP:0008066 Abnormal blistering of the skin Very frequent (99-80%)
HP:0010783 Erythema Very frequent (99-80%)
HP:0012733 Macule Very frequent (99-80%)
HP:0200037 Skin vesicle Very frequent (99-80%)
HP:0000964 Eczema Frequent (79-30%)
HP:0000969 Edema Occasional (29-5%)
HP:0002653 Bone pain Occasional (29-5%)
HP:0100725 Lichenification Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 73

HPO ID Term # of case reports
HP:0010783 Erythema 10
HP:0000819 Diabetes mellitus 6
HP:0000112 Nephropathy 5
HP:0001045 Vitiligo 5
HP:0001025 Urticaria 4
HP:0000099 Glomerulonephritis 3
HP:0000967 Petechiae 3
HP:0002090 Pneumonia 3
HP:0011473 Villous atrophy 3
HP:0032282 Contact dermatitis 3
HP:0100646 Thyroiditis 3
HP:0000836 Hyperthyroidism 2
HP:0001271 Polyneuropathy 2
HP:0001370 Rheumatoid arthritis 2
HP:0012234 Agranulocytosis 2
HP:0025615 Abscess 2
HP:0030731 Carcinoma 2
HP:0100242 Sarcoma 2
HP:0200034 Papule 2
HP:0000083 Renal insufficiency 1
HP:0000100 Nephrotic syndrome 1
HP:0000230 Gingivitis 1
HP:0000763 Sensory neuropathy 1
HP:0000771 Gynecomastia 1
HP:0000821 Hypothyroidism 1
HP:0000829 Hypoparathyroidism 1
HP:0000846 Adrenal insufficiency 1
HP:0000952 Jaundice 1
HP:0000964 Eczema 1
HP:0000969 Edema 1
HP:0000988 Skin rash 1
HP:0001101 Iritis 1
HP:0001251 Ataxia 1
HP:0001369 Arthritis 1
HP:0001396 Cholestasis 1
HP:0001508 Failure to thrive 1
HP:0001638 Cardiomyopathy 1
HP:0001701 Pericarditis 1
HP:0001733 Pancreatitis 1
HP:0001744 Splenomegaly 1
HP:0001891 Iron deficiency anemia 1
HP:0001903 Anemia 1
HP:0002013 Vomiting 1
HP:0002014 Diarrhea 1
HP:0002019 Constipation 1
HP:0002024 Malabsorption 1
HP:0002027 Abdominal pain 1
HP:0002243 Protein-losing enteropathy 1
HP:0002254 Intermittent diarrhea 1
HP:0002570 Steatorrhea 1
HP:0002583 Colitis 1
HP:0002862 Bladder carcinoma 1
HP:0002900 Hypokalemia 1
HP:0002960 Autoimmunity 1
HP:0003198 Myopathy 1
HP:0004322 Short stature 1
HP:0005523 Lymphoproliferative disorder 1
HP:0009830 Peripheral neuropathy 1
HP:0011837 Partial IgA deficiency 1
HP:0012180 Cystic medial necrosis 1
HP:0012378 Fatigue 1
HP:0012393 Allergy 1
HP:0012538 Gluten intolerance 1
HP:0012722 Heart block 1
HP:0025084 Folliculitis 1
HP:0031364 Ecchymosis 1
HP:0031500 Abdominal mass 1
HP:0040075 Hypopituitarism 1
HP:0100279 Ulcerative colitis 1
HP:0100614 Myositis 1
HP:0100699 Scarring 1
HP:0100753 Schizophrenia 1
HP:0100820 Glomerulopathy 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID