Leishmaniasis

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration).

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Narrow down the case reports

Total: 884 (papers)

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Matched Phenotype Gene Mutation MeSH

Rank (Similarity)	PMID (PMCID)
1 (57.1%)	24850963 (4028457)	Visceral leishmaniasis without fever in an 11-month-old infant: a rare clinical feature of Kala-azar. Sayyahfar S, Ansari S, Mohebali M, Behnam B. Korean J Parasitol. 2014;52(2):189-91. [ Show abstract ] [ Hide abstract ]
		Hepatosplenomegaly Splenomegaly Anemia Fever


		Anemia Antiprotozoal Agents Differential Diagnosis Drug Combinations Endemic Diseases Fever Homo sapiens Infant Iran Leishmania infantum Leishmaniasis, Visceral Male Organometallic Compounds Splenomegaly
1 (57.1%)	18351544	Visceral leishmaniasis as a rare cause of granulomatosis hepatitis: a case report. Yazici P, Yeniay L, Aydin U, Tasbakan M, Ozutemiz O, Yilmaz R. Turkiye Parazitol Derg. 2008;32(1):12-5. [ Show abstract ] [ Hide abstract ]
		Splenomegaly Anemia Fever Hepatic granulomatosis


		Adult Differential Diagnosis Females Granuloma Hepatitis A Homo sapiens Leishmaniasis, Visceral Liver Spleen
1 (57.1%)	10953559	[Hematologic characteristics of leishmaniasis]. Belic A, Pejin D, Stefanovic N, Spasojevic J, Durkovic D. Med Pregl. 2000;53(1-2):89-91. [ Show abstract ] [ Hide abstract ]
		Splenomegaly Anemia Fever Hepatomegaly


		Adult Differential Diagnosis Females Hematologic Tests Homo sapiens Leishmaniasis
4 (56.2%)	30083074	Kala-Azar and leukemia: A rare association. Bay A, Aktekin EH, Eksi F, Ozcan M. Turk Pediatri Ars. 2018;53(1):45-47. [ Show abstract ] [ Hide abstract ]
		Splenomegaly Anemia Fever



4 (56.2%)	24412871	[Co-occurence of visceral leishmaniasis and lymphoma]. Erdem A, Tasbakan M, Pullukcu H, Toz SO, Sipahi OR, Yamazhan T, Turgay N. Turkiye Parazitol Derg. 2013;37(4):282-4. [ Show abstract ] [ Hide abstract ]
		Splenomegaly Anemia Fever


		Abdominal Pain Anemia Anticestodal Agents Bone Marrow Diffuse Large B-Cell Lymphoma Females Fever of Unknown Origin Homo sapiens Hypergammaglobulinemia Leishmaniasis, Visceral Middle Aged Splenomegaly X-Ray Computed Tomography
4 (56.2%)	23682278 (3655258)	Bone marrow negative visceral leishmaniasis in an adolescent male. Jetley S, Rana S, Khan S, Zeeba J, Hassan M, Kapoor P. Iran J Parasitol. 2013;8(1):182-5. [ Show abstract ] [ Hide abstract ]
		Splenomegaly Anemia Fever



4 (56.2%)	22393633	[Visceral leishmaniasis: pediatric case report observed outside the traditional foci in Cameroon]. Mbassi Awa HD, Pondy A, Njiki Kinkela M, Lebela J, Koki Ndombo PO. Med Trop (Mars). 2011;71(6):618-20. [ Show abstract ] [ Hide abstract ]
		Splenomegaly Anemia Fever


		Cameroon Child Endemic Diseases Geography Homo sapiens Leishmaniasis, Visceral Male
4 (56.2%)	15225352 (459222)	Visceral leishmaniasis caused by Leishmania infantum in a Spanish patient in Argentina: What is the origin of the infection? Case report. Martin-Sanchez J, Navarro-Mari JM, Pasquau-Liano J, Salomon OD, Morillas-Marquez F. BMC Infect Dis. 2004;4:20. [ Show abstract ] [ Hide abstract ]
		Splenomegaly Anemia Fever


		Animals Antibodies, Protozoan Bone Marrow Brazil Cuba DNA, Kinetoplast Differential Diagnosis Electrophoresis, Starch Gel Enzyme-Linked Immunosorbent Assay Females Fluorescent Antibody Technique, Indirect Homo sapiens Isoenzymes Leishmania infantum Leishmaniasis, Visceral Mexico Polymerase Chain Reaction Random Amplified Polymorphic DNA Technique Spain
4 (56.2%)	3198462	Visceral leishmaniasis in an English foxhound from an Ohio research colony. Swenson CL, Silverman J, Stromberg PC, Johnson SE, Wilkie DA, Eaton KA, Kociba GJ. J Am Vet Med Assoc. 1988;193(9):1089-92. [ Show abstract ] [ Hide abstract ]
		Proteinuria Splenomegaly Anemia


		Animals Animals, Laboratory Canis familiaris Dog Diseases Leishmaniasis, Visceral Male Ohio
10 (55.1%)	30787856	Visceral Leishmaniasis and Glomerulonephritis: A Case Report. Alwazzeh MJ, Alhashimalsayed ZH. Saudi J Med Med Sci. 2019;7(1):40-43. [ Show abstract ] [ Hide abstract ]
		Hepatosplenomegaly Anemia Fever

Phenotype(s) retrieved from Orphanet

Total: 25

HPO ID	Term	Frequency
HP:0000163	Abnormal oral cavity morphology	Very frequent (99-80%)
HP:0001744	Splenomegaly	Very frequent (99-80%)
HP:0001876	Pancytopenia	Very frequent (99-80%)
HP:0001892	Abnormal bleeding	Very frequent (99-80%)
HP:0001954	Recurrent fever	Very frequent (99-80%)
HP:0002240	Hepatomegaly	Very frequent (99-80%)
HP:0002716	Lymphadenopathy	Very frequent (99-80%)
HP:0004311	Abnormal macrophage morphology	Very frequent (99-80%)
HP:0011830	Abnormal oral mucosa morphology	Very frequent (99-80%)
HP:0012384	Rhinitis	Very frequent (99-80%)
HP:0030166	Night sweats	Very frequent (99-80%)
HP:0200034	Papule	Very frequent (99-80%)
HP:0200035	Skin plaque	Very frequent (99-80%)
HP:0200042	Skin ulcer	Very frequent (99-80%)
HP:0000980	Pallor	Frequent (79-30%)
HP:0001824	Weight loss	Frequent (79-30%)
HP:0001903	Anemia	Frequent (79-30%)
HP:0002829	Arthralgia	Frequent (79-30%)
HP:0002910	Elevated hepatic transaminase	Frequent (79-30%)
HP:0003073	Hypoalbuminemia	Frequent (79-30%)
HP:0010702	Increased antibody level in blood	Frequent (79-30%)
HP:0001873	Thrombocytopenia	Occasional (29-5%)
HP:0001882	Leukopenia	Occasional (29-5%)
HP:0002039	Anorexia	Occasional (29-5%)
HP:0012378	Fatigue	Occasional (29-5%)

Phenotype(s) retrieved from case reports

Total: 178

HPO ID	Term	# of case reports
HP:0001945	Fever	63
HP:0002721	Immunodeficiency	58
HP:0031690	Opportunistic infection	38
HP:0001876	Pancytopenia	33
HP:0001744	Splenomegaly	25
HP:0001433	Hepatosplenomegaly	22
HP:0002835	Aspiration	21
HP:0001903	Anemia	14
HP:0002716	Lymphadenopathy	14
HP:0032252	Granuloma	14
HP:0012115	Hepatitis	13
HP:0001370	Rheumatoid arthritis	12
HP:0200034	Papule	9
HP:0001824	Weight loss	7
HP:0002860	Squamous cell carcinoma	7
HP:0000099	Glomerulonephritis	6
HP:0001873	Thrombocytopenia	6
HP:0012156	Hemophagocytosis	6
HP:0100726	Kaposi's sarcoma	6
HP:0000819	Diabetes mellitus	5
HP:0000999	Pyoderma	5
HP:0001369	Arthritis	5
HP:0001882	Leukopenia	5
HP:0030350	Erythematous papule	5
HP:0100699	Scarring	5
HP:0000964	Eczema	4
HP:0001055	Erysipelas	4
HP:0001733	Pancreatitis	4
HP:0001818	Paronychia	4
HP:0002028	Chronic diarrhea	4
HP:0002039	Anorexia	4
HP:0002090	Pneumonia	4
HP:0002840	Lymphadenitis	4
HP:0002955	Granulomatosis	4
HP:0012490	Panniculitis	4
HP:0012735	Cough	4
HP:0030731	Carcinoma	4
HP:0032169	Severe infection	4
HP:0100658	Cellulitis	4
HP:0100727	Histiocytosis	4
HP:0200123	Chronic hepatitis	4
HP:0000821	Hypothyroidism	3
HP:0001394	Cirrhosis	3
HP:0001482	Subcutaneous nodule	3
HP:0001664	Torsade de pointes	3
HP:0002202	Pleural effusion	3
HP:0002671	Basal cell carcinoma	3
HP:0032163	Molluscum contagiosum	3
HP:0000083	Renal insufficiency	2
HP:0000100	Nephrotic syndrome	2
HP:0000123	Nephritis	2
HP:0000491	Keratitis	2
HP:0000509	Conjunctivitis	2
HP:0000573	Retinal hemorrhage	2
HP:0001289	Confusion	2
HP:0001409	Portal hypertension	2
HP:0001880	Eosinophilia	2
HP:0001909	Leukemia	2
HP:0001919	Acute kidney injury	2
HP:0002014	Diarrhea	2
HP:0002027	Abdominal pain	2
HP:0002240	Hepatomegaly	2
HP:0002586	Peritonitis	2
HP:0002863	Myelodysplasia	2
HP:0004326	Cachexia	2
HP:0004395	Malnutrition	2
HP:0004844	Coombs-positive hemolytic anemia	2
HP:0005523	Lymphoproliferative disorder	2
HP:0006515	Interstitial pneumonitis	2
HP:0012378	Fatigue	2
HP:0025084	Folliculitis	2
HP:0025474	Erythematous plaque	2
HP:0025615	Abscess	2
HP:0031273	Shock	2
HP:0100584	Endocarditis	2
HP:0100721	Mediastinal lymphadenopathy	2
HP:0100806	Sepsis	2
HP:0200042	Skin ulcer	2
HP:0410017	Otitis externa	2
HP:0000024	Prostatitis	1
HP:0000093	Proteinuria	1
HP:0000155	Oral ulcer	1
HP:0000360	Tinnitus	1
HP:0000421	Epistaxis	1
HP:0000498	Blepharitis	1
HP:0000501	Glaucoma	1
HP:0000613	Photophobia	1
HP:0000618	Blindness	1
HP:0000622	Blurred vision	1
HP:0000656	Ectropion	1
HP:0000704	Periodontitis	1
HP:0000752	Hyperactivity	1
HP:0000789	Infertility	1
HP:0000832	Primary hypothyroidism	1
HP:0000846	Adrenal insufficiency	1
HP:0000969	Edema	1
HP:0000979	Purpura	1
HP:0000989	Pruritus	1
HP:0001025	Urticaria	1
HP:0001045	Vitiligo	1
HP:0001047	Atopic dermatitis	1
HP:0001075	Atrophic scars	1
HP:0001082	Cholecystitis	1
HP:0001128	Trichiasis	1
HP:0001250	Seizures	1
HP:0001287	Meningitis	1
HP:0001300	Parkinsonism	1
HP:0001324	Muscle weakness	1
HP:0001337	Tremor	1
HP:0001488	Bilateral ptosis	1
HP:0001541	Ascites	1
HP:0001657	Prolonged QT interval	1
HP:0001701	Pericarditis	1
HP:0001735	Acute pancreatitis	1
HP:0001742	Nasal obstruction	1
HP:0001878	Hemolytic anemia	1
HP:0001888	Lymphopenia	1
HP:0001913	Granulocytopenia	1
HP:0001954	Recurrent fever	1
HP:0001955	Unexplained fevers	1
HP:0002013	Vomiting	1
HP:0002018	Nausea	1
HP:0002094	Dyspnea	1
HP:0002099	Asthma	1
HP:0002102	Pleuritis	1
HP:0002105	Hemoptysis	1
HP:0002149	Hyperuricemia	1
HP:0002152	Hyperproteinemia	1
HP:0002153	Hyperkalemia	1
HP:0002155	Hypertriglyceridemia	1
HP:0002248	Hematemesis	1
HP:0002315	Headache	1
HP:0002664	Neoplasm	1
HP:0002754	Osteomyelitis	1
HP:0002779	Tracheomalacia	1
HP:0002829	Arthralgia	1
HP:0002905	Hyperphosphatemia	1
HP:0002960	Autoimmunity	1
HP:0003073	Hypoalbuminemia	1
HP:0003095	Septic arthritis	1
HP:0003146	Hypocholesterolemia	1
HP:0003201	Rhabdomyolysis	1
HP:0003326	Myalgia	1
HP:0004787	Fulminant hepatitis	1
HP:0005521	Disseminated intravascular coagulation	1
HP:0006689	Bacterial endocarditis	1
HP:0008677	Congenital nephrotic syndrome	1
HP:0008940	Generalized lymphadenopathy	1
HP:0010550	Paraplegia	1
HP:0010605	Chalazion	1
HP:0010783	Erythema	1
HP:0011110	Tonsillitis	1
HP:0011675	Arrhythmia	1
HP:0011974	Myelofibrosis	1
HP:0012219	Erythema nodosum	1
HP:0012224	Circulating immune complexes	1
HP:0012234	Agranulocytosis	1
HP:0020071	Viremia	1
HP:0025059	Splenic abscess	1
HP:0025143	Chills	1
HP:0025581	Foveal hemorrhage	1
HP:0030839	Knee pain	1
HP:0030955	Alcoholism	1
HP:0031002	Neuritis	1
HP:0031035	Chronic infection	1
HP:0031525	Keratoacanthoma	1
HP:0031677	Polymorphic ventricular tachycardia	1
HP:0031805	Intraretinal hemorrhage	1
HP:0032282	Contact dermatitis	1
HP:0040186	Maculopapular exanthema	1
HP:0100279	Ulcerative colitis	1
HP:0100523	Liver abscess	1
HP:0100550	Tendon rupture	1
HP:0100561	Spinal cord lesion	1
HP:0100633	Esophagitis	1
HP:0200036	Skin nodule	1
HP:0200043	Verrucae	1
HP:0550004	Verruca plana	1

Causative gene(s) retrieved from Orphanet

Total: 0

Gene Symbol	Gene Name	Entrez Gene ID