Leishmaniasis

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration).



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Narrow down the case reports



Total: 884 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
10
(55.1%)
26573264
Foveal hemorrhage in an immunocompetent patient with visceral leishmaniasis.
Cibils Farres P, Bedoya Ayala P, Burga Kuroda GH, Zegarra Dominguez M, Luna JD, Velazco Casapia J.
Arch Soc Esp Oftalmol. 2015;90(12):597-9.
Hepatosplenomegaly Anemia Fever
Adult Animals Antiprotozoal Agents Blood Transfusion Canis familiaris Combined Modality Therapy Dog Diseases Endemic Diseases Hepatitis A Homo sapiens Immunocompetence Leishmaniasis, Visceral Male Paraguay Retinal Hemorrhage Scotoma Zoonoses
10
(55.1%)
25617995
[Macrophage activation syndrome and autoimmunity due to visceral leishmaniasis].
Higel L, Froehlich C, Pages MP, Dupont D, Collardeau-Frachon S, Dijoud F, Cochat P, Belot A.
Arch Pediatr. 2015;22(4):397-400.
Hepatosplenomegaly Anemia Fever
FXN
Homo sapiens Infant Leishmaniasis, Visceral Macrophage Activation Syndrome Male
10
(55.1%)
22219568
(3249709)
Atypical presentation of visceral leishmaniasis in a HIV-positive patient from a nonendemic area.
Vyas DH, Shah PD.
J Lab Physicians. 2011;3(2):119-21.
Hepatosplenomegaly Anemia Low-grade fever
10
(55.1%)
21063981
[An adult case of visceral leishmaniasis in a province of Black-Sea region, Turkey].
Oztoprak N, Aydemir H, Piskin N, Seremet Keskin A, Arasl M, Gokmen A, Celebi G, Kulekci Ugur A, Taylan Ozkan A.
Mikrobiyol Bul. 2010;44(4):671-7.
Hepatosplenomegaly Anemia Fever
CRP
Adult Antibodies, Protozoan Bone Marrow Differential Diagnosis Hepatomegaly Homo sapiens Leishmaniasis, Visceral Liver Male Pancytopenia Splenomegaly Transaminases
10
(55.1%)
12458816
Visceral leishmaniasis and Coombs' positive hemolytic anemia: a rare association in an infant treated with liposomal amphotericin B.
Dilber E, Erduran E, Isik Y.
Turk J Pediatr. 2002;44(4):354-6.
Hepatosplenomegaly Anemia Fever
Anemia, Hemolytic Antiprotozoal Agents Coombs Test Females Homo sapiens Infant Leishmaniasis, Visceral Liposomes
10
(55.1%)
12219147
Concurrent cutaneous, visceral and ocular leishmaniasis caused by Leishmania (Viannia) braziliensis in a kidney transplant patient.
Gontijo CM, Pacheco RS, Orefice F, Lasmar E, Silva ES, Melo MN.
Mem Inst Oswaldo Cruz. 2002;97(5):751-3.
Hepatosplenomegaly Anemia Fever
Adult Animals Eye Infections, Parasitic Fatal Outcome Homo sapiens Kidney Transplantation Leishmania braziliensis Leishmaniasis, Cutaneous Leishmaniasis, Visceral Male
10
(55.1%)
11444445
Anesthetic considerations in a patient with visceral leishmaniasis.
Dubey PK, Sinha PK, Raghwendra KH.
Can J Anaesth. 2001;48(6):529-31.
Hepatosplenomegaly Anemia Hypoalbuminemia
Appendectomy Electrocardiography General Anesthesia Homo sapiens Leishmaniasis, Visceral Male Monitoring, Physiologic
10
(55.1%)
7885958
[Anemia and hepatosplenomegaly: search for the protozoon?].
La Placa G, Muschiato M, Arlati S, Urbano M, Verdura C.
Pediatr Med Chir. 1994;16(5):475-7.
Hepatosplenomegaly Anemia Hypoalbuminemia
Anemia Animals Differential Diagnosis Hepatomegaly Homo sapiens Infant Leishmania donovani Leishmaniasis, Visceral Male Splenomegaly
10
(55.1%)
1662324
Visceral leishmaniasis in an HIV-infected patient: clinical features and response to treatment.
Fenske S, Stellbrink HJ, Albrecht H, Greten H.
Klin Wochenschr. 1991;69(17):793-6.
Hepatosplenomegaly Anemia Fever
CD4
Adult HIV Infections HIV-1 Homo sapiens Leishmaniasis, Visceral Male Opportunistic Infections
10
(55.1%)
1338013
Imported kala-azar: a case report.
Yu KW, Chow MP, Hsu NW, Liu CY, Yeh HS, Liu SM, Fan PC.
Zhonghua Yi Xue Za Zhi (Taipei). 1992;50(5):411-4.
Hepatosplenomegaly Anemia Fever
Homo sapiens Leishmaniasis, Visceral Male
        

Phenotype(s) retrieved from Orphanet

    Total: 25

HPO ID Term Frequency
HP:0000163 Abnormal oral cavity morphology Very frequent (99-80%)
HP:0001744 Splenomegaly Very frequent (99-80%)
HP:0001876 Pancytopenia Very frequent (99-80%)
HP:0001892 Abnormal bleeding Very frequent (99-80%)
HP:0001954 Recurrent fever Very frequent (99-80%)
HP:0002240 Hepatomegaly Very frequent (99-80%)
HP:0002716 Lymphadenopathy Very frequent (99-80%)
HP:0004311 Abnormal macrophage morphology Very frequent (99-80%)
HP:0011830 Abnormal oral mucosa morphology Very frequent (99-80%)
HP:0012384 Rhinitis Very frequent (99-80%)
HP:0030166 Night sweats Very frequent (99-80%)
HP:0200034 Papule Very frequent (99-80%)
HP:0200035 Skin plaque Very frequent (99-80%)
HP:0200042 Skin ulcer Very frequent (99-80%)
HP:0000980 Pallor Frequent (79-30%)
HP:0001824 Weight loss Frequent (79-30%)
HP:0001903 Anemia Frequent (79-30%)
HP:0002829 Arthralgia Frequent (79-30%)
HP:0002910 Elevated hepatic transaminase Frequent (79-30%)
HP:0003073 Hypoalbuminemia Frequent (79-30%)
HP:0010702 Increased antibody level in blood Frequent (79-30%)
HP:0001873 Thrombocytopenia Occasional (29-5%)
HP:0001882 Leukopenia Occasional (29-5%)
HP:0002039 Anorexia Occasional (29-5%)
HP:0012378 Fatigue Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 178

HPO ID Term # of case reports
HP:0001945 Fever 63
HP:0002721 Immunodeficiency 58
HP:0031690 Opportunistic infection 38
HP:0001876 Pancytopenia 33
HP:0001744 Splenomegaly 25
HP:0001433 Hepatosplenomegaly 22
HP:0002835 Aspiration 21
HP:0001903 Anemia 14
HP:0002716 Lymphadenopathy 14
HP:0032252 Granuloma 14
HP:0012115 Hepatitis 13
HP:0001370 Rheumatoid arthritis 12
HP:0200034 Papule 9
HP:0001824 Weight loss 7
HP:0002860 Squamous cell carcinoma 7
HP:0000099 Glomerulonephritis 6
HP:0001873 Thrombocytopenia 6
HP:0012156 Hemophagocytosis 6
HP:0100726 Kaposi's sarcoma 6
HP:0000819 Diabetes mellitus 5
HP:0000999 Pyoderma 5
HP:0001369 Arthritis 5
HP:0001882 Leukopenia 5
HP:0030350 Erythematous papule 5
HP:0100699 Scarring 5
HP:0000964 Eczema 4
HP:0001055 Erysipelas 4
HP:0001733 Pancreatitis 4
HP:0001818 Paronychia 4
HP:0002028 Chronic diarrhea 4
HP:0002039 Anorexia 4
HP:0002090 Pneumonia 4
HP:0002840 Lymphadenitis 4
HP:0002955 Granulomatosis 4
HP:0012490 Panniculitis 4
HP:0012735 Cough 4
HP:0030731 Carcinoma 4
HP:0032169 Severe infection 4
HP:0100658 Cellulitis 4
HP:0100727 Histiocytosis 4
HP:0200123 Chronic hepatitis 4
HP:0000821 Hypothyroidism 3
HP:0001394 Cirrhosis 3
HP:0001482 Subcutaneous nodule 3
HP:0001664 Torsade de pointes 3
HP:0002202 Pleural effusion 3
HP:0002671 Basal cell carcinoma 3
HP:0032163 Molluscum contagiosum 3
HP:0000083 Renal insufficiency 2
HP:0000100 Nephrotic syndrome 2
HP:0000123 Nephritis 2
HP:0000491 Keratitis 2
HP:0000509 Conjunctivitis 2
HP:0000573 Retinal hemorrhage 2
HP:0001289 Confusion 2
HP:0001409 Portal hypertension 2
HP:0001880 Eosinophilia 2
HP:0001909 Leukemia 2
HP:0001919 Acute kidney injury 2
HP:0002014 Diarrhea 2
HP:0002027 Abdominal pain 2
HP:0002240 Hepatomegaly 2
HP:0002586 Peritonitis 2
HP:0002863 Myelodysplasia 2
HP:0004326 Cachexia 2
HP:0004395 Malnutrition 2
HP:0004844 Coombs-positive hemolytic anemia 2
HP:0005523 Lymphoproliferative disorder 2
HP:0006515 Interstitial pneumonitis 2
HP:0012378 Fatigue 2
HP:0025084 Folliculitis 2
HP:0025474 Erythematous plaque 2
HP:0025615 Abscess 2
HP:0031273 Shock 2
HP:0100584 Endocarditis 2
HP:0100721 Mediastinal lymphadenopathy 2
HP:0100806 Sepsis 2
HP:0200042 Skin ulcer 2
HP:0410017 Otitis externa 2
HP:0000024 Prostatitis 1
HP:0000093 Proteinuria 1
HP:0000155 Oral ulcer 1
HP:0000360 Tinnitus 1
HP:0000421 Epistaxis 1
HP:0000498 Blepharitis 1
HP:0000501 Glaucoma 1
HP:0000613 Photophobia 1
HP:0000618 Blindness 1
HP:0000622 Blurred vision 1
HP:0000656 Ectropion 1
HP:0000704 Periodontitis 1
HP:0000752 Hyperactivity 1
HP:0000789 Infertility 1
HP:0000832 Primary hypothyroidism 1
HP:0000846 Adrenal insufficiency 1
HP:0000969 Edema 1
HP:0000979 Purpura 1
HP:0000989 Pruritus 1
HP:0001025 Urticaria 1
HP:0001045 Vitiligo 1
HP:0001047 Atopic dermatitis 1
HP:0001075 Atrophic scars 1
HP:0001082 Cholecystitis 1
HP:0001128 Trichiasis 1
HP:0001250 Seizures 1
HP:0001287 Meningitis 1
HP:0001300 Parkinsonism 1
HP:0001324 Muscle weakness 1
HP:0001337 Tremor 1
HP:0001488 Bilateral ptosis 1
HP:0001541 Ascites 1
HP:0001657 Prolonged QT interval 1
HP:0001701 Pericarditis 1
HP:0001735 Acute pancreatitis 1
HP:0001742 Nasal obstruction 1
HP:0001878 Hemolytic anemia 1
HP:0001888 Lymphopenia 1
HP:0001913 Granulocytopenia 1
HP:0001954 Recurrent fever 1
HP:0001955 Unexplained fevers 1
HP:0002013 Vomiting 1
HP:0002018 Nausea 1
HP:0002094 Dyspnea 1
HP:0002099 Asthma 1
HP:0002102 Pleuritis 1
HP:0002105 Hemoptysis 1
HP:0002149 Hyperuricemia 1
HP:0002152 Hyperproteinemia 1
HP:0002153 Hyperkalemia 1
HP:0002155 Hypertriglyceridemia 1
HP:0002248 Hematemesis 1
HP:0002315 Headache 1
HP:0002664 Neoplasm 1
HP:0002754 Osteomyelitis 1
HP:0002779 Tracheomalacia 1
HP:0002829 Arthralgia 1
HP:0002905 Hyperphosphatemia 1
HP:0002960 Autoimmunity 1
HP:0003073 Hypoalbuminemia 1
HP:0003095 Septic arthritis 1
HP:0003146 Hypocholesterolemia 1
HP:0003201 Rhabdomyolysis 1
HP:0003326 Myalgia 1
HP:0004787 Fulminant hepatitis 1
HP:0005521 Disseminated intravascular coagulation 1
HP:0006689 Bacterial endocarditis 1
HP:0008677 Congenital nephrotic syndrome 1
HP:0008940 Generalized lymphadenopathy 1
HP:0010550 Paraplegia 1
HP:0010605 Chalazion 1
HP:0010783 Erythema 1
HP:0011110 Tonsillitis 1
HP:0011675 Arrhythmia 1
HP:0011974 Myelofibrosis 1
HP:0012219 Erythema nodosum 1
HP:0012224 Circulating immune complexes 1
HP:0012234 Agranulocytosis 1
HP:0020071 Viremia 1
HP:0025059 Splenic abscess 1
HP:0025143 Chills 1
HP:0025581 Foveal hemorrhage 1
HP:0030839 Knee pain 1
HP:0030955 Alcoholism 1
HP:0031002 Neuritis 1
HP:0031035 Chronic infection 1
HP:0031525 Keratoacanthoma 1
HP:0031677 Polymorphic ventricular tachycardia 1
HP:0031805 Intraretinal hemorrhage 1
HP:0032282 Contact dermatitis 1
HP:0040186 Maculopapular exanthema 1
HP:0100279 Ulcerative colitis 1
HP:0100523 Liver abscess 1
HP:0100550 Tendon rupture 1
HP:0100561 Spinal cord lesion 1
HP:0100633 Esophagitis 1
HP:0200036 Skin nodule 1
HP:0200043 Verrucae 1
HP:0550004 Verruca plana 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID