Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).



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Narrow down the case reports



Total: 128 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
116
(9.2%)
8199573
Cold agglutinin disease following allogeneic bone marrow transplantation.
Tamura T, Kanamori H, Yamazaki E, Ohtsuka M, Hataoka K, Maeda K, Okamoto R, Tanabe J, Fujita H, Hashimoto Y, et al..
Bone Marrow Transplant. 1994;13(3):321-3.
Pericarditis
CSF3
Adult Bone Marrow Transplantation Graft-vs-Host Disease Homo sapiens Incidence Male Transplantation, Homologous
116
(9.2%)
7436651
Cold agglutinin disease in a patient with Legionnaires' disease.
King JW, May JS.
Arch Intern Med. 1980;140(11):1537-9.
Pneumonia
Agglutinins Cold Temperature Homo sapiens Legionnaires' Disease Male
116
(9.2%)
6874334
[Livedo reticularis: dermatologic alarm signal in cold agglutinin disease].
Trenkwalder B, Schonitzer D, Lisch H, Breier C, Klein G, Hintner H.
Hautarzt. 1983;34(6):273-6.
Pneumonia
Adult Agglutinins Cryoglobulins Differential Diagnosis Erythema Erythrocytes Exchange Transfusion, Whole Blood Homo sapiens Male Skin Pigmentation
116
(9.2%)
6815128
[Post-infectious temporary cold agglutinin disease. A case of delayed formation of antibodies against Mycoplasma pneumoniae].
Kovary PM, Geisen HP, Ebeling A.
Hautarzt. 1982;33(8):420-3.
Pneumonia
Adult Agglutinins Antibodies, Bacterial Cryoglobulins Homo sapiens Male Mycoplasma pneumoniae Skin
116
(9.2%)
3844005
Cold agglutinin syndrome: nursing management.
Donham JA, Denning V.
Heart Lung. 1985;14(1):59-67.
Pneumonia
BCAR1
Acute Disease Blood Transfusion Combined Modality Therapy Erythrocytes Females Homo sapiens Immunoglobulin M Middle Aged Plasmapheresis
126
(5.0%)
20213090
[Rheumatoid arthritis and autoimmune hemolysis: B-cell depletion for remission induction in a patient with rheumatoid arthritis and cold agglutinin disease].
Lehmann P, Hartung W, Ehrenstein B, Scholmerich J, Fleck M.
Z Rheumatol. 2010;69(6):557-60.
Arthritis
Antibodies, Monoclonal, Murine-Derived Antirheumatic Agents B-Lymphocytes Cryoglobulins Females Homo sapiens Immunoglobulin lambda-Chains Lymphocyte Depletion Rheumatoid Arthritis
126
(5.0%)
17880618
Rituximab as successful therapy in a patient with refractory paroxysmal cold hemoglobinuria.
Koppel A, Lim S, Osby M, Garratty G, Goldfinger D.
Transfusion. 2007;47(10):1902-4.
Fatigue
Anemia Antibodies, Monoclonal, Murine-Derived Females Hemoglobinuria, Paroxysmal Homo sapiens Immunologic Factors Middle Aged Monoclonal Antibodies
126
(5.0%)
8261977
Paroxysmal cold haemoglobinuria coexisting with cold agglutinins in a patient with syphilis resulting in peripheral gangrene: a case report.
Patel M, Durao H, Govender Y.
East Afr Med J. 1993;70(8):526-7.
Gangrene
Amputation Gangrene Hemoglobinuria, Paroxysmal Homo sapiens Male Middle Aged Peripheral Vascular Diseases Syphilis
        

Phenotype(s) retrieved from Orphanet

    Total: 14

HPO ID Term Frequency
HP:0000980 Pallor Very frequent (99-80%)
HP:0001324 Muscle weakness Very frequent (99-80%)
HP:0001878 Hemolytic anemia Very frequent (99-80%)
HP:0002829 Arthralgia Very frequent (99-80%)
HP:0002960 Autoimmunity Very frequent (99-80%)
HP:0012378 Fatigue Very frequent (99-80%)
HP:0001744 Splenomegaly Occasional (29-5%)
HP:0002014 Diarrhea Occasional (29-5%)
HP:0002017 Nausea and vomiting Occasional (29-5%)
HP:0002240 Hepatomegaly Occasional (29-5%)
HP:0002315 Headache Occasional (29-5%)
HP:0002716 Lymphadenopathy Occasional (29-5%)
HP:0003418 Back pain Occasional (29-5%)
HP:0012086 Abnormal urinary color Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 41

HPO ID Term # of case reports
HP:0002090 Pneumonia 8
HP:0002045 Hypothermia 7
HP:0001878 Hemolytic anemia 6
HP:0001903 Anemia 6
HP:0005523 Lymphoproliferative disorder 6
HP:0001063 Acrocyanosis 5
HP:0001909 Leukemia 5
HP:0100778 Cryoglobulinemia 4
HP:0001945 Fever 3
HP:0001907 Thromboembolism 2
HP:0100758 Gangrene 2
HP:0000099 Glomerulonephritis 1
HP:0000518 Cataract 1
HP:0000952 Jaundice 1
HP:0000980 Pallor 1
HP:0001082 Cholecystitis 1
HP:0001271 Polyneuropathy 1
HP:0001342 Cerebral hemorrhage 1
HP:0001370 Rheumatoid arthritis 1
HP:0001394 Cirrhosis 1
HP:0001433 Hepatosplenomegaly 1
HP:0001744 Splenomegaly 1
HP:0001919 Acute kidney injury 1
HP:0002027 Abdominal pain 1
HP:0002204 Pulmonary embolism 1
HP:0002637 Cerebral ischemia 1
HP:0002647 Aortic dissection 1
HP:0002716 Lymphadenopathy 1
HP:0002904 Hyperbilirubinemia 1
HP:0002908 Conjugated hyperbilirubinemia 1
HP:0009830 Peripheral neuropathy 1
HP:0011946 Bronchiolitis obliterans 1
HP:0012156 Hemophagocytosis 1
HP:0025289 Cervical lymphadenopathy 1
HP:0030880 Raynaud phenomenon 1
HP:0031047 Paraproteinemia 1
HP:0031284 Flushing 1
HP:0100242 Sarcoma 1
HP:0100727 Histiocytosis 1
HP:0100806 Sepsis 1
HP:0410135 Cold urticaria 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID