Cold agglutinin disease

Cold agglutinin disease is a type of autoimmune hemolytic anemia (see this term) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30°C).



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Narrow down the case reports



Total: 128 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(60.1%)		 21378480
 [Low-titer cold agglutinin disease following Salmonella gastroenteritis].
Kobayashi K, Hamaki T, Ohwada A, Tomiyama J, Sakuma R, Mizuta Y, Moriyama A, Yamamoto E, Akiya I, Fujita H.
Rinsho Ketsueki. 2011;52(1):32-6.
Cyanosis Anemia Fever Diarrhea Spherocytosis
Anemia, Hemolytic Gastroenteritis Homo sapiens Male Middle Aged
2
(59.3%)		 7526015
 [Chronic cold agglutinin disease accompanied with an increase of CD20+/CD5+ cells; a case report].
Notoya A, Hirayama S, Takano H, Koizumi K, Satoh N, Yasukouchi T, Sawada K, Koike T.
Rinsho Ketsueki. 1994;35(9):881-5.
Acrocyanosis Hepatosplenomegaly Erythroid hyperplasia Dark urine
CD5 KRT20
Antigens, CD5 Antigens, Differentiation, B-Lymphocyte CD Antigens CD20 Antigens Chronic Lymphocytic Leukemia Differential Diagnosis Homo sapiens Male Middle Aged
3
(56.2%)		 29683945
 EBV-related Cold Agglutinin Disease Presenting With Conjugated Hyperbilirubinemia: A Pediatric Case Report and Mini Review.
Mantadakis E, Chatzimichael E, Kontekaki E, Panopoulou M, Martinis G, Tsalkidis A.
J Pediatr Hematol Oncol. 2019;41(4):324-327.
Splenomegaly Hemolytic anemia Conjugated hyperbilirubinemia
Child Females Homo sapiens Hyperbilirubinemia Infectious Mononucleosis
3
(56.2%)		 28321090
 Splenic marginal zone lymphoma complicated by cold agglutinin disease.
Ochi K, Yokoyama K, Ohno N, Ota Y, Tojo A.
Rinsho Ketsueki. 2017;58(2):132-137.
Splenomegaly Anemia Fever
ANPEP IL2RA ITGAX KRT20
Females Homo sapiens Middle Aged Mucosa-Associated Lymphoid Tissue Lymphoma Splenectomy Splenic Neoplasms
5
(55.1%)		 6807086
 B-cell neoplasms with homogeneous cold-reacting antibodies (cold agglutinins).
Crisp D, Pruzanski W.
Am J Med. 1982;72(6):915-22.
Hepatosplenomegaly Anemia Bence Jones Proteinuria
Adult B-Lymphocytes Homo sapiens Immunoglobulin M Lymphoma Male Middle Aged Waldenstrom Macroglobulinemia
5
(55.1%)		 1331564
 [Anti-Pr2 cold agglutinin disease with polyneuropathy evolving to malignant lymphoma].
Takai K, Sanada M, Shibuya H.
Rinsho Ketsueki. 1992;33(9):1231-6.
Hepatosplenomegaly Hemolytic anemia Fever
B-Cell Lymphomas Homo sapiens Immunoglobulin M Immunoglobulin kappa-Chains Male Middle Aged Paraproteinemias Peripheral Nervous System Diseases
7
(54.4%)		 1469790
 [Chronic cold agglutinin disease terminating in primary macroglobulinemia after a 10 year history].
Ozaki S, Kawachi Y, Sakamoto Y, Igaki T, Ogasawara N, Uchida T, Mori M, Setu K.
Rinsho Ketsueki. 1992;33(11):1720-4.
Jaundice Hepatosplenomegaly Anemia
Agglutinins Cryoglobulins Homo sapiens Male Waldenstrom Macroglobulinemia
8
(52.2%)		 29885944
 Cold agglutinin disease complicating management of aortic dissection.
Bras J, Uminski K, Ponnampalam A.
Transfus Apher Sci. 2018;57(2):236-238.
Acrocyanosis Hemolytic anemia Hypothermia Aortic dissection
Aneurysm, Dissecting Homo sapiens Male
9
(51.4%)		 11235130
 [Systemic inflammatory response syndrome triggered by necrotizing cholecystitis after treatment of underlying low titer cold agglutinin disease].
Nagahama M, Kagawa H, Ozaki Y, Onishi S, Ishida T, Nomura S, Fukuhara S.
Rinsho Ketsueki. 2001;42(1):23-9.
Cholecystitis Hemolytic anemia Fever
IL6 TNF
Anti-Inflammatory Agents Cholecystitis Homo sapiens Male Systemic Inflammatory Response Syndrome
10
(50.6%)		 8296193
 [Treatment of severe idiopathic cold-agglutinin diseases using interferon-alpha 2b].
Rordorf R, Barth A, Nydegger U, Tobler A.
Schweiz Med Wochenschr. 1994;124(1-2):56-61.
Acrocyanosis Hemolytic anemia Leukemia Hemoglobinuria
IFNA2
Bilirubin Combined Modality Therapy Females Hemoglobin Homo sapiens Interferon alpha 2 Interferon-alpha Middle Aged Recombinant Proteins Reticulocytes
        

Phenotype(s) retrieved from Orphanet

    Total: 14

HPO ID Term Frequency
HP:0000980 Pallor Very frequent (99-80%)
HP:0001324 Muscle weakness Very frequent (99-80%)
HP:0001878 Hemolytic anemia Very frequent (99-80%)
HP:0002829 Arthralgia Very frequent (99-80%)
HP:0002960 Autoimmunity Very frequent (99-80%)
HP:0012378 Fatigue Very frequent (99-80%)
HP:0001744 Splenomegaly Occasional (29-5%)
HP:0002014 Diarrhea Occasional (29-5%)
HP:0002017 Nausea and vomiting Occasional (29-5%)
HP:0002240 Hepatomegaly Occasional (29-5%)
HP:0002315 Headache Occasional (29-5%)
HP:0002716 Lymphadenopathy Occasional (29-5%)
HP:0003418 Back pain Occasional (29-5%)
HP:0012086 Abnormal urinary color Occasional (29-5%)


Phenotype(s) retrieved from case reports

    Total: 41

HPO ID Term # of case reports
HP:0002090 Pneumonia 8
HP:0002045 Hypothermia 7
HP:0001878 Hemolytic anemia 6
HP:0001903 Anemia 6
HP:0005523 Lymphoproliferative disorder 6
HP:0001063 Acrocyanosis 5
HP:0001909 Leukemia 5
HP:0100778 Cryoglobulinemia 4
HP:0001945 Fever 3
HP:0001907 Thromboembolism 2
HP:0100758 Gangrene 2
HP:0000099 Glomerulonephritis 1
HP:0000518 Cataract 1
HP:0000952 Jaundice 1
HP:0000980 Pallor 1
HP:0001082 Cholecystitis 1
HP:0001271 Polyneuropathy 1
HP:0001342 Cerebral hemorrhage 1
HP:0001370 Rheumatoid arthritis 1
HP:0001394 Cirrhosis 1
HP:0001433 Hepatosplenomegaly 1
HP:0001744 Splenomegaly 1
HP:0001919 Acute kidney injury 1
HP:0002027 Abdominal pain 1
HP:0002204 Pulmonary embolism 1
HP:0002637 Cerebral ischemia 1
HP:0002647 Aortic dissection 1
HP:0002716 Lymphadenopathy 1
HP:0002904 Hyperbilirubinemia 1
HP:0002908 Conjugated hyperbilirubinemia 1
HP:0009830 Peripheral neuropathy 1
HP:0011946 Bronchiolitis obliterans 1
HP:0012156 Hemophagocytosis 1
HP:0025289 Cervical lymphadenopathy 1
HP:0030880 Raynaud phenomenon 1
HP:0031047 Paraproteinemia 1
HP:0031284 Flushing 1
HP:0100242 Sarcoma 1
HP:0100727 Histiocytosis 1
HP:0100806 Sepsis 1
HP:0410135 Cold urticaria 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID