Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.



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Narrow down the case reports



Total: 220 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
1
(56.2%)		 29390349
(5815761)
 Sjogren's syndrome manifesting as clinicopathological features of TAFRO syndrome: A case report.
Fujimoto S, Kawabata H, Kurose N, Kawanami-Iwao H, Sakai T, Kawanami T, Fujita Y, Fukushima T, Masaki Y.
Medicine (Baltimore). 2017;96(50):e9220.
Splenomegaly Anemia Fever
CRP
Adult Differential Diagnosis Females Glucocorticoids Homo sapiens Sjogren's Syndrome
1
(56.2%)		 26354576
 Colchicine therapy in amyloidosis related with plasmacytic Castleman disease presenting with nephrotic syndrome.
Paydas S, Paydas S, Ergin M.
Saudi J Kidney Dis Transpl. 2015;26(5):992-5.
Splenomegaly Anemia Fever
Adult Amyloidosis Angiotensin-Converting Enzyme Inhibitors Biopsy CD38 Antigen Combination Drug Therapy Homo sapiens Immunohistochemistry Male Membrane Glycoproteins Nephrotic Syndrome Time Factors
1
(56.2%)		 25873122
 [PET-CT documented remission of multicentric Castleman disease after treatment with rituximab: case report and review].
Adam Z, Szturz P, Koukalova R, ehak Z, Pour L, Kreji M, mardova L, Eid M, Volfova P, ermakova Z, Ken L, Sokol F, Hanke I, Michalkova E, Kral Z, Mayer J.
Vnitr Lek. 2015;61(3):251-9.
Splenomegaly Anemia Fever
DDIT3 IL6
Antibodies, Monoclonal, Murine-Derived Combination Drug Therapy Homo sapiens Immunologic Factors Multimodal Imaging Positron-Emission Tomography X-Ray Computed Tomography
1
(56.2%)		 22032720
 Castleman disease in a pediatric liver transplant recipient: a case report and literature review.
Bonatti HJ, Axt J, Hunter EB, Lott SL, Frangoul H, Gillis L, Correa H, Kelly B.
Pediatr Transplant. 2012;16(6):E229-34.
Splenomegaly Anemia Fever
CPS1 KRT20
Adult B-Lymphocytes CD20 Antigens CD3 Antigens Graft Survival Homo sapiens Immunosuppressive Agents Infant, Newborn Liver Failure Lymphatic Diseases Male Middle Aged Polymerase Chain Reaction Splenomegaly T-Lymphocyte X-Ray Computed Tomography
1
(56.2%)		 19301455
 Antiglomerular basement membrane disease associated with Castleman disease.
Lv J, Zhang H, Zhou F, Zou W, Singh AK, Wang H.
Am J Med Sci. 2009;337(3):206-9.
Hematuria Splenomegaly Anemia
IL6
Adult Anti-Glomerular Basement Membrane Disease Follow-Up Studies Homo sapiens Male
6
(55.1%)		 28580156
(5451894)
 Castleman's disease with TAFRO syndrome: a case report from Syria.
Alhoulaiby S, Ahmad B, Alrstom A, Kudsi M.
Oxf Med Case Reports. 2017;2017(6):omx021.
Edema Hepatosplenomegaly Microcytic anemia
6
(55.1%)		 18701866
 [A Japanese case of human herpes virus-8-associated multicentric castleman disease complicated by hemophagocytic syndrome].
Miyagi T, Nagasaki A, Taira T, Yamanoha A, Taira N, Aonahata M, Yoshimi N, Ohshima K, Takasu N.
Gan To Kagaku Ryoho. 2008;35(8):1431-4.
Hepatosplenomegaly Anemia Fever
Homo sapiens Lymphohistiocytosis, Hemophagocytic Male Middle Aged
6
(55.1%)		 11061358
 The heterogeneity of Castleman disease: report of five cases and review of the literature.
Maslovsky I, Uriev L, Lugassy G.
Am J Med Sci. 2000;320(4):292-5.
Hepatosplenomegaly Anemia Hypoalbuminemia
Aged, 80 and over Differential Diagnosis Females Fever Homo sapiens Lymphatic Diseases Male Muscle Weakness Sweating
9
(50.0%)		 30906603
 Castleman Disease in a Patient with Common Variable Immunodeficiency.
Ricciardi L, Furci F, Ieni A, Macri A.
Case Reports Immunol. 2019;2019:5476383.
Splenomegaly Anemia
10
(49.7%)		 26980221
 Successful treatment of TAFRO syndrome, a variant type of multicentric Castleman disease with thrombotic microangiopathy, with anti-IL-6 receptor antibody and steroids.
Fujiwara S, Mochinaga H, Nakata H, Ohshima K, Matsumoto M, Uchiba M, Mikami Y, Hata H, Okuno Y, Mitsuya H, Nosaka K.
Int J Hematol. 2016;103(6):718-23.
Edema Ascites Anemia
ADAMTS13 IL6
ADAMTS13 Protein Antibodies Antibodies, Monoclonal, Humanized Differential Diagnosis Homo sapiens Interleukin 6 Receptor Male Middle Aged Steroids Thrombotic Microangiopathies
        

Phenotype(s) retrieved from Orphanet

    Total: 29

HPO ID Term Frequency
HP:0002716 Lymphadenopathy Very frequent (99-80%)
HP:0001824 Weight loss Frequent (79-30%)
HP:0001903 Anemia Frequent (79-30%)
HP:0002027 Abdominal pain Frequent (79-30%)
HP:0002729 Follicular hyperplasia Frequent (79-30%)
HP:0003565 Elevated erythrocyte sedimentation rate Frequent (79-30%)
HP:0011227 Elevated C-reactive protein level Frequent (79-30%)
HP:0012378 Fatigue Frequent (79-30%)
HP:0025142 Constitutional symptom Frequent (79-30%)
HP:0030783 Increased serum interleukin-6 Frequent (79-30%)
HP:0100721 Mediastinal lymphadenopathy Frequent (79-30%)
HP:0000952 Jaundice Occasional (29-5%)
HP:0002017 Nausea and vomiting Occasional (29-5%)
HP:0003270 Abdominal distention Occasional (29-5%)
HP:0008940 Generalized lymphadenopathy Occasional (29-5%)
HP:0011024 Abnormality of the gastrointestinal tract Occasional (29-5%)
HP:0012735 Cough Occasional (29-5%)
HP:0025066 Decreased mean corpuscular volume Occasional (29-5%)
HP:0030157 Flank pain Occasional (29-5%)
HP:0031500 Abdominal mass Occasional (29-5%)
HP:0000083 Renal insufficiency Very rare (4-1%)
HP:0000790 Hematuria Very rare (4-1%)
HP:0001723 Restrictive cardiomyopathy Very rare (4-1%)
HP:0001873 Thrombocytopenia Very rare (4-1%)
HP:0002094 Dyspnea Very rare (4-1%)
HP:0005214 Intestinal obstruction Very rare (4-1%)
HP:0006000 Ureteral obstruction Very rare (4-1%)
HP:0011974 Myelofibrosis Very rare (4-1%)
HP:0012050 Anasarca Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 63

HPO ID Term # of case reports
HP:0005523 Lymphoproliferative disorder 36
HP:0002716 Lymphadenopathy 8
HP:0001271 Polyneuropathy 7
HP:0030731 Carcinoma 7
HP:0002664 Neoplasm 5
HP:0001945 Fever 4
HP:0002721 Immunodeficiency 4
HP:0030150 Plasmacytosis 4
HP:0000969 Edema 3
HP:0001744 Splenomegaly 3
HP:0001903 Anemia 3
HP:0031501 Pelvic mass 3
HP:0100242 Sarcoma 3
HP:0001028 Hemangioma 2
HP:0001433 Hepatosplenomegaly 2
HP:0001891 Iron deficiency anemia 2
HP:0002729 Follicular hyperplasia 2
HP:0008940 Generalized lymphadenopathy 2
HP:0011974 Myelofibrosis 2
HP:0031500 Abdominal mass 2
HP:0000100 Nephrotic syndrome 1
HP:0000112 Nephropathy 1
HP:0000135 Hypogonadism 1
HP:0000572 Visual loss 1
HP:0000790 Hematuria 1
HP:0000819 Diabetes mellitus 1
HP:0000821 Hypothyroidism 1
HP:0000846 Adrenal insufficiency 1
HP:0000952 Jaundice 1
HP:0001138 Optic neuropathy 1
HP:0001370 Rheumatoid arthritis 1
HP:0001541 Ascites 1
HP:0001873 Thrombocytopenia 1
HP:0001894 Thrombocytosis 1
HP:0001909 Leukemia 1
HP:0001935 Microcytic anemia 1
HP:0001955 Unexplained fevers 1
HP:0002024 Malabsorption 1
HP:0002027 Abdominal pain 1
HP:0002094 Dyspnea 1
HP:0002617 Dilatation 1
HP:0002668 Paraganglioma 1
HP:0002835 Aspiration 1
HP:0002960 Autoimmunity 1
HP:0003072 Hypercalcemia 1
HP:0003073 Hypoalbuminemia 1
HP:0003418 Back pain 1
HP:0005200 Retroperitoneal fibrosis 1
HP:0005521 Disseminated intravascular coagulation 1
HP:0009830 Peripheral neuropathy 1
HP:0010280 Stomatitis 1
HP:0011134 Low-grade fever 1
HP:0011506 Choroidal neovascularization 1
HP:0011510 Drusen 1
HP:0011946 Bronchiolitis obliterans 1
HP:0012050 Anasarca 1
HP:0012432 Chronic fatigue 1
HP:0012593 Nephrotic range proteinuria 1
HP:0025289 Cervical lymphadenopathy 1
HP:0032046 Focal cortical dysplasia 1
HP:0100008 Schwannoma 1
HP:0100632 Pulmonary sequestration 1
HP:0100726 Kaposi's sarcoma 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID