Castleman disease

Castleman disease (CD) is a benign lymphoproliferative disorder that may present as a localized or multicentric form (see these terms). The clinical manifestations are heterogeneous, ranging from asymptomatic discrete lymphadenopathy to recurrent episodes of diffuse lymphadenopathy with severe systemic symptoms.



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Narrow down the case reports



Total: 220 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
11
(48.9%)		 27741115
(5072942)
 Case report and literature review: Glomerular and neurologic thrombotic microangiopathy as a primary manifestation of multicentric castleman disease.
Flahault A, Vignon M, Rabant M, Hummel A, Noel LH, Canioni D, Knebelmann B, Suarez F, El Karoui K.
Medicine (Baltimore). 2016;95(41):e5047.
Anemia Fever Diarrhea Lymphadenopathy
Biopsy Differential Diagnosis Homo sapiens Kidney Glomerulus Male Middle Aged Thrombotic Microangiopathies
12
(48.9%)		 16415667
 Abdominal Castleman disease with mixed histopathology in a patient with iron deficiency anemia, growth retardation and peliosis hepatis.
Saritas U, Ustundag Y, Isitan G, Bastugrul S, Erekul S.
Am J Med Sci. 2006;331(1):51-4.
Iron deficiency anemia Hepatomegaly
Abdomen Adult Growth Disorders Homo sapiens Peliosis Hepatis Ultrasonography
13
(46.2%)		 26137030
 Budd-Chiari syndrome, a rare complication of multicentric Castleman disease: A case report.
Song K, Li M.
Oncol Lett. 2015;9(5):2153-2156.
Edema Splenomegaly Intracranial hemorrhage Hepatomegaly
14
(45.3%)		 23094815
 [Our experience in treatment of multicentric plasma-cell Castleman disease associated with vasculitis manifestations - case report and literature review].
Szturz P, Adam Z, Moulis M, Smardova L, Klincova M, Slaisova R, Koukalova R, Rehak Z, Volfova P, Chovancova J, Stehlikova O, Mayer J.
Vnitr Lek. 2012;58(9):679-90.
Edema Splenomegaly Thromboembolism
Homo sapiens Male Middle Aged Vasculitis
14
(45.3%)		 16922487
 [A case of HIV-1 and HHV-8-associated Castleman disease with a relapsing high fever and lymphoadenopathy].
Minami R, Yamamoto M.
Kansenshogaku Zasshi. 2006;80(4):423-7.
Splenomegaly Thrombocytopenia Fever
CD4 IL2RB
HIV Infections HIV-1 Herpesviridae Infections Homo sapiens Lymphatic Diseases Male Middle Aged Relapsing Fever
16
(44.2%)		 29901607
(6023668)
 Membranoproliferative glomerulonephritis-like findings for TAFRO syndrome, associated with an anterior mediastinal tumor: A case report.
Furuto Y, Hashimoto H, Horiuti H, Shibuya Y.
Medicine (Baltimore). 2018;97(24):e11057.
Proteinuria Hepatosplenomegaly Thrombocytopenia
Females Glomerulonephritis, Membranoproliferative Glucocorticoids Homo sapiens Kidney Mediastinal Neoplasms Mediastinum Middle Aged Positron-Emission Tomography X-Ray Computed Tomography
16
(44.2%)		 29879072
(5999464)
 Successful treatment with tacrolimus in TAFRO syndrome: two case reports and literature review.
Shirai T, Onishi A, Waki D, Saegusa J, Morinobu A.
Medicine (Baltimore). 2018;97(23):e11045.
Hepatosplenomegaly Thrombocytopenia Fever
IL6 NELFCD
Bone Marrow Cardiomyopathies Edema Females Fever Fibrosis Glucocorticoids Hepatomegaly Homo sapiens Male Primary Myelofibrosis Renal Insufficiency Splenomegaly Syndrome Thrombocytopenia
16
(44.2%)		 26634133
(4664845)
 Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS syndrome): a paraneoplastic syndrome.
Kumar S, Sharma S.
Oxf Med Case Reports. 2015;2015(3):237-40.
Edema Thrombocytosis Hepatomegaly
MYOM2 VEGFA
16
(44.2%)		 20534952
 [Thrombocytopenia with mild bone marrow fibrosis accompanied by fever, pleural effusion, ascites and hepatosplenomegaly].
Takai K, Nikkuni K, Shibuya H, Hashidate H.
Rinsho Ketsueki. 2010;51(5):320-5.
Hepatosplenomegaly Thrombocytopenia Fever
DDIT3
Ascites Differential Diagnosis Fatal Outcome Females Fever Hepatomegaly Homo sapiens Immunosuppressive Agents Male Middle Aged Primary Myelofibrosis Splenomegaly Syndrome Thrombocytopenia
16
(44.2%)		 16860182
 Renal involvement in multicentric Castleman disease with glomeruloid hemangioma of skin and plasmacytoma.
Uthup S, Balachandran K, Ammal VA, Abdul Salam R, George J, Nair GM, Leela M.
Am J Kidney Dis. 2006;48(2):e17-24.
Proteinuria Hepatomegaly Plasmacytosis
Biopsy Glomerulonephritis, Membranoproliferative Hemangioma Homo sapiens Immunosuppressive Agents Male Middle Aged Plasmacytoma Skin Neoplasms Steroids
        

Phenotype(s) retrieved from Orphanet

    Total: 29

HPO ID Term Frequency
HP:0002716 Lymphadenopathy Very frequent (99-80%)
HP:0001824 Weight loss Frequent (79-30%)
HP:0001903 Anemia Frequent (79-30%)
HP:0002027 Abdominal pain Frequent (79-30%)
HP:0002729 Follicular hyperplasia Frequent (79-30%)
HP:0003565 Elevated erythrocyte sedimentation rate Frequent (79-30%)
HP:0011227 Elevated C-reactive protein level Frequent (79-30%)
HP:0012378 Fatigue Frequent (79-30%)
HP:0025142 Constitutional symptom Frequent (79-30%)
HP:0030783 Increased serum interleukin-6 Frequent (79-30%)
HP:0100721 Mediastinal lymphadenopathy Frequent (79-30%)
HP:0000952 Jaundice Occasional (29-5%)
HP:0002017 Nausea and vomiting Occasional (29-5%)
HP:0003270 Abdominal distention Occasional (29-5%)
HP:0008940 Generalized lymphadenopathy Occasional (29-5%)
HP:0011024 Abnormality of the gastrointestinal tract Occasional (29-5%)
HP:0012735 Cough Occasional (29-5%)
HP:0025066 Decreased mean corpuscular volume Occasional (29-5%)
HP:0030157 Flank pain Occasional (29-5%)
HP:0031500 Abdominal mass Occasional (29-5%)
HP:0000083 Renal insufficiency Very rare (4-1%)
HP:0000790 Hematuria Very rare (4-1%)
HP:0001723 Restrictive cardiomyopathy Very rare (4-1%)
HP:0001873 Thrombocytopenia Very rare (4-1%)
HP:0002094 Dyspnea Very rare (4-1%)
HP:0005214 Intestinal obstruction Very rare (4-1%)
HP:0006000 Ureteral obstruction Very rare (4-1%)
HP:0011974 Myelofibrosis Very rare (4-1%)
HP:0012050 Anasarca Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 63

HPO ID Term # of case reports
HP:0005523 Lymphoproliferative disorder 36
HP:0002716 Lymphadenopathy 8
HP:0001271 Polyneuropathy 7
HP:0030731 Carcinoma 7
HP:0002664 Neoplasm 5
HP:0001945 Fever 4
HP:0002721 Immunodeficiency 4
HP:0030150 Plasmacytosis 4
HP:0000969 Edema 3
HP:0001744 Splenomegaly 3
HP:0001903 Anemia 3
HP:0031501 Pelvic mass 3
HP:0100242 Sarcoma 3
HP:0001028 Hemangioma 2
HP:0001433 Hepatosplenomegaly 2
HP:0001891 Iron deficiency anemia 2
HP:0002729 Follicular hyperplasia 2
HP:0008940 Generalized lymphadenopathy 2
HP:0011974 Myelofibrosis 2
HP:0031500 Abdominal mass 2
HP:0000100 Nephrotic syndrome 1
HP:0000112 Nephropathy 1
HP:0000135 Hypogonadism 1
HP:0000572 Visual loss 1
HP:0000790 Hematuria 1
HP:0000819 Diabetes mellitus 1
HP:0000821 Hypothyroidism 1
HP:0000846 Adrenal insufficiency 1
HP:0000952 Jaundice 1
HP:0001138 Optic neuropathy 1
HP:0001370 Rheumatoid arthritis 1
HP:0001541 Ascites 1
HP:0001873 Thrombocytopenia 1
HP:0001894 Thrombocytosis 1
HP:0001909 Leukemia 1
HP:0001935 Microcytic anemia 1
HP:0001955 Unexplained fevers 1
HP:0002024 Malabsorption 1
HP:0002027 Abdominal pain 1
HP:0002094 Dyspnea 1
HP:0002617 Dilatation 1
HP:0002668 Paraganglioma 1
HP:0002835 Aspiration 1
HP:0002960 Autoimmunity 1
HP:0003072 Hypercalcemia 1
HP:0003073 Hypoalbuminemia 1
HP:0003418 Back pain 1
HP:0005200 Retroperitoneal fibrosis 1
HP:0005521 Disseminated intravascular coagulation 1
HP:0009830 Peripheral neuropathy 1
HP:0010280 Stomatitis 1
HP:0011134 Low-grade fever 1
HP:0011506 Choroidal neovascularization 1
HP:0011510 Drusen 1
HP:0011946 Bronchiolitis obliterans 1
HP:0012050 Anasarca 1
HP:0012432 Chronic fatigue 1
HP:0012593 Nephrotic range proteinuria 1
HP:0025289 Cervical lymphadenopathy 1
HP:0032046 Focal cortical dysplasia 1
HP:0100008 Schwannoma 1
HP:0100632 Pulmonary sequestration 1
HP:0100726 Kaposi's sarcoma 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID