Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.



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Narrow down the case reports



Total: 234 (papers)

  


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)
PMID
(PMCID)
1
(50.5%)
204668
The glucagonoma syndrome.
Shupack JL, Berczeller PH, Stevens DM.
J Dermatol Surg Oncol. 1978;4(3):242-7.
Diabetes mellitus Anemia Neoplasm of the pancreas Necrolytic migratory erythema
Adult Complications of Diabetes Mellitus Females Homo sapiens Islet Cell Adenoma Pancreatic Neoplasm Syndrome
2
(49.1%)
29688432
Glucagonoma With Necrolytic Migratory Erythema: Metabolic Profile and Detection of Biallelic Inactivation of DAXX Gene.
Tamura A, Ogasawara T, Fujii Y, Kaneko H, Nakayama A, Higuchi S, Hashimoto N, Miyabayashi Y, Fujimoto M, Komai E, Kono T, Sakuma I, Nagano H, Suzuki S, Koide H, Yokote K, Iseki K, Oguma R, Matsue H, Nojima H, Sugiura K, Yoshitomi H, Ohtsuka M, Rahmutulla B, Kaneda A, Inoshita N, Ogawa S, Tanaka T.
J Clin Endocrinol Metab. 2018;103(7):2417-2423.
Insulin resistance Anemia Necrolytic migratory erythema
Adaptor Proteins, Signal Transducing Alleles Co-Repressor Proteins Females Gene Silencing Glucagonoma Homo sapiens Metabolome Middle Aged Molecular Chaperones Necrolytic Migratory Erythema Nuclear Proteins Pancreatic Neoplasm
2
(49.1%)
28138636
Glucagonoma syndrome: report of one case.
Han X, Wang D, Kuang T, Rong Y, Lou W.
Transl Gastroenterol Hepatol. 2016;1:70.
Anemia Hyperglycemia Erythema
CEACAM5 CHGA ENO2 SSR2 SYNM
2
(49.1%)
23644134
[Diagnosis and treatment of glucagonoma: report of one case].
Cheng H, Chen M, Yang G.
Nan Fang Yi Ke Da Xue Xue Bao. 2013;33(4):618-insidebackcover.
Diabetes mellitus Anemia Necrolytic migratory erythema
Glucagonoma Homo sapiens Male Middle Aged Pancreatectomy Pancreatic Neoplasm
2
(49.1%)
21859461
(3171381)
Glucagonoma syndrome: a case report.
Castro PG, de Leon AM, Trancon JG, Martinez PA, Alvarez Perez JA, Fernandez Fernandez JC, Garcia Bernardo CM, Serra LB, Gonzalez Gonzalez JJ.
J Med Case Rep. 2011;5:402.
Diabetes mellitus Anemia Necrolytic migratory erythema
2
(49.1%)
17926496
[A case of pancreatic glucagonoma].
Simonenko VB, Dulin PA, Beliaev LB, Makanin MA, Dem'ianenko AV, Zykova AA, Zhuravleva SI, Kolesnikova VN.
Klin Med (Mosk). 2007;85(8):67-70.
Diabetes mellitus Anemia Erythema
Biopsy Diabetes Mellitus, Non-Insulin-Dependent Females Glucagonoma Homo sapiens Laparotomy Middle Aged Pancreatic Neoplasm
2
(49.1%)
15959605
Rare presentation of endocrine pancreatic tumor: a case of diffuse glucagonoma without metastasis and necrolytic migratory erythema.
Chen HW, Chen HW, Su DH, Shun CT, Liu KL.
J Formos Med Assoc. 2005;104(5):363-6.
Diabetes mellitus Anemia Necrolytic migratory erythema
Glucagonoma Homo sapiens Male Middle Aged Pancreatectomy Pancreatic Neoplasm
2
(49.1%)
15313692
Clinical experience in diagnosis and treatment of glucagonoma syndrome.
Zhang M, Xu X, Shen Y, Hu ZH, Wu LM, Zheng SS.
Hepatobiliary Pancreat Dis Int. 2004;3(3):473-5.
Diabetes mellitus Anemia Necrolytic migratory erythema
Glucagonoma Homo sapiens Magnetic Resonance Imaging Male Middle Aged Pancreatic Neoplasm
2
(49.1%)
12918465
Malignant glucagonoma of the pancreas diagnoses through anemia and diabetes mellitus.
Koike N, Hatori T, Imaizumi T, Harada N, Fukuda A, Takasaki K, Iwamoto Y.
J Hepatobiliary Pancreat Surg. 2003;10(1):101-5.
Diabetes mellitus Anemia Necrolytic migratory erythema
CHGA EPO
Anemia Complications of Diabetes Mellitus Glucagonoma Homo sapiens Male Pancreatectomy Pancreatic Neoplasm Splenectomy
2
(49.1%)
12434103
[Clinical response of an atypical glucagonoma treated with a long-acting somatostatin analog].
Bouin M, Aoust LD.
Gastroenterol Clin Biol. 2002;26(10):926-9.
Diabetes mellitus Anemia Erythema
SST
Antineoplastic Agents, Hormonal Diabetes Mellitus, Non-Insulin-Dependent Glucagonoma Homo sapiens Male Pancreatic Neoplasm
        

Phenotype(s) retrieved from Orphanet

    Total: 42

HPO ID Term Frequency
HP:0002894 Neoplasm of the pancreas Very frequent (99-80%)
HP:0000206 Glossitis Frequent (79-30%)
HP:0000819 Diabetes mellitus Frequent (79-30%)
HP:0000988 Skin rash Frequent (79-30%)
HP:0000989 Pruritus Frequent (79-30%)
HP:0001824 Weight loss Frequent (79-30%)
HP:0001895 Normochromic anemia Frequent (79-30%)
HP:0001927 Acanthocytosis Frequent (79-30%)
HP:0002014 Diarrhea Frequent (79-30%)
HP:0002017 Nausea and vomiting Frequent (79-30%)
HP:0002019 Constipation Frequent (79-30%)
HP:0002039 Anorexia Frequent (79-30%)
HP:0002240 Hepatomegaly Frequent (79-30%)
HP:0002574 Episodic abdominal pain Frequent (79-30%)
HP:0004396 Poor appetite Frequent (79-30%)
HP:0008066 Abnormal blistering of the skin Frequent (79-30%)
HP:0010280 Stomatitis Frequent (79-30%)
HP:0012432 Chronic fatigue Frequent (79-30%)
HP:0031181 Necrolytic migratory erythema Frequent (79-30%)
HP:0000716 Depressivity Occasional (29-5%)
HP:0001046 Intermittent jaundice Occasional (29-5%)
HP:0001406 Intrahepatic cholestasis Occasional (29-5%)
HP:0001438 Abnormality of abdomen morphology Occasional (29-5%)
HP:0001541 Ascites Occasional (29-5%)
HP:0001907 Thromboembolism Occasional (29-5%)
HP:0002239 Gastrointestinal hemorrhage Occasional (29-5%)
HP:0002570 Steatorrhea Occasional (29-5%)
HP:0005214 Intestinal obstruction Occasional (29-5%)
HP:0012334 Extrahepatic cholestasis Occasional (29-5%)
HP:0030145 Lack of bowel sounds Occasional (29-5%)
HP:0030895 Abnormal gastrointestinal motility Occasional (29-5%)
HP:0000820 Abnormality of the thyroid gland Very rare (4-1%)
HP:0000837 Increased circulating gonadotropin level Very rare (4-1%)
HP:0000845 Growth hormone excess Very rare (4-1%)
HP:0000870 Prolactin excess Very rare (4-1%)
HP:0001031 Subcutaneous lipoma Very rare (4-1%)
HP:0001578 None Very rare (4-1%)
HP:0002893 Pituitary adenoma Very rare (4-1%)
HP:0002897 Parathyroid adenoma Very rare (4-1%)
HP:0003072 Hypercalcemia Very rare (4-1%)
HP:0008200 Primary hyperparathyroidism Very rare (4-1%)
HP:0008256 Adrenocortical adenoma Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 61

HPO ID Term # of case reports
HP:0031181 Necrolytic migratory erythema 79
HP:0001824 Weight loss 30
HP:0001903 Anemia 23
HP:0000819 Diabetes mellitus 21
HP:0010783 Erythema 14
HP:0002664 Neoplasm 10
HP:0030731 Carcinoma 8
HP:0001952 Glucose intolerance 6
HP:0010280 Stomatitis 6
HP:0000206 Glossitis 5
HP:0000988 Skin rash 5
HP:0030405 Pancreatic endocrine tumor 5
HP:0001953 Diabetic ketoacidosis 4
HP:0002024 Malabsorption 4
HP:0003074 Hyperglycemia 4
HP:0002014 Diarrhea 3
HP:0100825 Cheilitis 3
HP:0000843 Hyperparathyroidism 2
HP:0001513 Obesity 2
HP:0001733 Pancreatitis 2
HP:0001943 Hypoglycemia 2
HP:0002900 Hypokalemia 2
HP:0004395 Malnutrition 2
HP:0004398 Peptic ulcer 2
HP:0004936 Venous thrombosis 2
HP:0031500 Abdominal mass 2
HP:0500167 Hypergastrinemia 2
HP:0000100 Nephrotic syndrome 1
HP:0000648 Optic atrophy 1
HP:0000726 Dementia 1
HP:0000842 Hyperinsulinemia 1
HP:0000964 Eczema 1
HP:0001251 Ataxia 1
HP:0001285 Spastic tetraparesis 1
HP:0001399 Hepatic failure 1
HP:0001433 Hepatosplenomegaly 1
HP:0001873 Thrombocytopenia 1
HP:0001993 Ketoacidosis 1
HP:0002028 Chronic diarrhea 1
HP:0002039 Anorexia 1
HP:0002204 Pulmonary embolism 1
HP:0002570 Steatorrhea 1
HP:0002625 Deep venous thrombosis 1
HP:0002666 Pheochromocytoma 1
HP:0002668 Paraganglioma 1
HP:0002894 Neoplasm of the pancreas 1
HP:0003072 Hypercalcemia 1
HP:0003073 Hypoalbuminemia 1
HP:0003075 Hypoproteinemia 1
HP:0005206 Pancreatic pseudocyst 1
HP:0005213 Pancreatic calcification 1
HP:0008200 Primary hyperparathyroidism 1
HP:0010566 Hamartoma 1
HP:0011736 Primary hyperaldosteronism 1
HP:0012115 Hepatitis 1
HP:0030016 Dyspareunia 1
HP:0030318 Angular cheilitis 1
HP:0031002 Neuritis 1
HP:0032368 Acidemia 1
HP:0040192 APUdoma 1
HP:0100792 Acantholysis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID