Glucagonoma

Glucagonoma is a rare, functioning type of pancreatic neuroendocrine tumor (PNET; see this term) that hypersecretes glucagon, leading to a syndrome comprised of necrolytic migratory erythema, diabetes mellitus, anemia, weight loss, mucosal abnormalities, thromboembolism, gastrointestinal and neuropsychiatric symptoms.



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Narrow down the case reports



Total: 234 (papers)

   


(per page)
Matched Phenotype  Gene  Mutation  MeSH
Rank
(Similarity)		 PMID
(PMCID)
2
(49.1%)		 12194691
 [Glucagonoma: evolution and treatment].
Carvajal C, Azabache V, Lobos P, Ibarra A.
Rev Med Chil. 2002;130(6):671-6.
Diabetes mellitus Anemia Necrolytic migratory erythema
Adult Dermatitis Glucagonoma Homo sapiens Male Pancreatic Neoplasm Paraneoplastic Syndromes
2
(49.1%)		 11836542
 Necrolytic migratory erythema associated with glucagonoma syndrome: a case report.
Dal Coleto CC, de Mello AP, Piquero-Casals J, Lima FR, Vilela MA, Festa-Neto C, Sanches JA Jr.
Rev Hosp Clin Fac Med Sao Paulo. 2001;56(6):183-8.
Anemia Glucose intolerance Erythema
Erythema Fatal Outcome Females Glucagonoma Homo sapiens Middle Aged Pancreatic Neoplasm Syndrome
2
(49.1%)		 10985071
 [Glucagon-secreting malignant neuroendocrine tumor of the pancreas].
Wickenhauser C, Aichelmann E, Neuhaus H, Holscher AH, Dienes HP.
Med Klin (Munich). 2000;95(8):466-9.
Diabetes mellitus Anemia Erythema
Adrenal Gland Neoplasms Diabetes Mellitus Differential Diagnosis Glucagonoma Homo sapiens Male Multiple Endocrine Neoplasia Pancreatic Neoplasm
2
(49.1%)		 10502856
 Glucagonoma syndrome: a case report.
Shyr YM, Su CH, Lee CH, Wu CW, Lui WY.
Zhonghua Yi Xue Za Zhi (Taipei). 1999;62(9):639-43.
Diabetes mellitus Anemia Necrolytic migratory erythema
Glucagonoma Homo sapiens Male Middle Aged Pancreatic Neoplasm
2
(49.1%)		 10457311
 Cystic glucagonoma: A rare variant of an uncommon neuroendocrine pancreas tumor.
Brown K, Kristopaitis T, Yong S, Chejfec G, Pickleman J.
J Gastrointest Surg. 1998;2(6):533-6.
Anemia Glucose intolerance Necrolytic migratory erythema
Adult Differential Diagnosis Glucagonoma Homo sapiens Immunohistochemistry Male Middle Aged Pancreatectomy Pancreatic Neoplasm Splenectomy
2
(49.1%)		 9927793
 [Pancreatic glucagonoma and deep vein thrombosis].
Guilarte Lopez-Manas J, Bellot Garcia V, Fernandez Perez R, Caballero Plasencia A.
Gastroenterol Hepatol. 1998;21(10):483-5.
Anemia Pulmonary embolism Hyperglycemia Erythema
Glucagonoma Homo sapiens Male Pancreatic Neoplasm Phlebitis
2
(49.1%)		 9201330
 [Glucagonoma: case report and literature review].
das Neves MM, Martins Junior EV, Gaburri AK, Chebli JM, Stavale JN, Herani Filho AK.
Arq Gastroenterol. 1996;33(3):167-72.
Anemia Glucose intolerance Necrolytic migratory erythema
Adult Glucagonoma Homo sapiens Male Pancreatic Neoplasm
2
(49.1%)		 7648942
 [Report of a case of glucagonoma misdiagnosed as "eczema" and "hepatic angioma" for three years and review of literature].
Dai W, Shi Y, Cai L.
Zhonghua Nei Ke Za Zhi. 1995;34(3):190-2.
Diabetes mellitus Anemia Necrolytic migratory erythema
Diagnostic Errors Eczema Glucagonoma Hemangioma Homo sapiens Male Middle Aged Pancreatectomy Pancreatic Neoplasm
2
(49.1%)		 6092443
 Glucagonoma syndrome: case report and literature review.
Parker CM, Hanke CW, Madura JA, Liss EC.
J Dermatol Surg Oncol. 1984;10(11):884-9.
Anemia Glucose intolerance Necrolytic migratory erythema
Amino Acids Dermatitis Diabetes Mellitus Differential Diagnosis Females Glucagonoma Homo sapiens Islet Cell Adenoma Middle Aged Pancreatic Neoplasm Paraneoplastic Syndromes Skin
2
(49.1%)		 2867823
 A functional study of a case of glucagonoma exhibiting typical glucagonoma syndrome.
Fujita J, Seino Y, Ishida H, Taminato T, Matsukura S, Horio T, Imamura S, Naito A, Tobe T, Takahashi K, et al..
Cancer. 1986;57(4):860-5.
Anemia Hypoglycemia Necrolytic migratory erythema
Blood Glucose Endocrine Glands Gastric Inhibitory Polypeptide Gel Chromatography Glucagonoma Homo sapiens Insulin Islet Cell Adenoma Male Middle Aged Pancreatic Neoplasm
        

Phenotype(s) retrieved from Orphanet

    Total: 42

HPO ID Term Frequency
HP:0002894 Neoplasm of the pancreas Very frequent (99-80%)
HP:0000206 Glossitis Frequent (79-30%)
HP:0000819 Diabetes mellitus Frequent (79-30%)
HP:0000988 Skin rash Frequent (79-30%)
HP:0000989 Pruritus Frequent (79-30%)
HP:0001824 Weight loss Frequent (79-30%)
HP:0001895 Normochromic anemia Frequent (79-30%)
HP:0001927 Acanthocytosis Frequent (79-30%)
HP:0002014 Diarrhea Frequent (79-30%)
HP:0002017 Nausea and vomiting Frequent (79-30%)
HP:0002019 Constipation Frequent (79-30%)
HP:0002039 Anorexia Frequent (79-30%)
HP:0002240 Hepatomegaly Frequent (79-30%)
HP:0002574 Episodic abdominal pain Frequent (79-30%)
HP:0004396 Poor appetite Frequent (79-30%)
HP:0008066 Abnormal blistering of the skin Frequent (79-30%)
HP:0010280 Stomatitis Frequent (79-30%)
HP:0012432 Chronic fatigue Frequent (79-30%)
HP:0031181 Necrolytic migratory erythema Frequent (79-30%)
HP:0000716 Depressivity Occasional (29-5%)
HP:0001046 Intermittent jaundice Occasional (29-5%)
HP:0001406 Intrahepatic cholestasis Occasional (29-5%)
HP:0001438 Abnormality of abdomen morphology Occasional (29-5%)
HP:0001541 Ascites Occasional (29-5%)
HP:0001907 Thromboembolism Occasional (29-5%)
HP:0002239 Gastrointestinal hemorrhage Occasional (29-5%)
HP:0002570 Steatorrhea Occasional (29-5%)
HP:0005214 Intestinal obstruction Occasional (29-5%)
HP:0012334 Extrahepatic cholestasis Occasional (29-5%)
HP:0030145 Lack of bowel sounds Occasional (29-5%)
HP:0030895 Abnormal gastrointestinal motility Occasional (29-5%)
HP:0000820 Abnormality of the thyroid gland Very rare (4-1%)
HP:0000837 Increased circulating gonadotropin level Very rare (4-1%)
HP:0000845 Growth hormone excess Very rare (4-1%)
HP:0000870 Prolactin excess Very rare (4-1%)
HP:0001031 Subcutaneous lipoma Very rare (4-1%)
HP:0001578 None Very rare (4-1%)
HP:0002893 Pituitary adenoma Very rare (4-1%)
HP:0002897 Parathyroid adenoma Very rare (4-1%)
HP:0003072 Hypercalcemia Very rare (4-1%)
HP:0008200 Primary hyperparathyroidism Very rare (4-1%)
HP:0008256 Adrenocortical adenoma Very rare (4-1%)


Phenotype(s) retrieved from case reports

    Total: 61

HPO ID Term # of case reports
HP:0031181 Necrolytic migratory erythema 79
HP:0001824 Weight loss 30
HP:0001903 Anemia 23
HP:0000819 Diabetes mellitus 21
HP:0010783 Erythema 14
HP:0002664 Neoplasm 10
HP:0030731 Carcinoma 8
HP:0001952 Glucose intolerance 6
HP:0010280 Stomatitis 6
HP:0000206 Glossitis 5
HP:0000988 Skin rash 5
HP:0030405 Pancreatic endocrine tumor 5
HP:0001953 Diabetic ketoacidosis 4
HP:0002024 Malabsorption 4
HP:0003074 Hyperglycemia 4
HP:0002014 Diarrhea 3
HP:0100825 Cheilitis 3
HP:0000843 Hyperparathyroidism 2
HP:0001513 Obesity 2
HP:0001733 Pancreatitis 2
HP:0001943 Hypoglycemia 2
HP:0002900 Hypokalemia 2
HP:0004395 Malnutrition 2
HP:0004398 Peptic ulcer 2
HP:0004936 Venous thrombosis 2
HP:0031500 Abdominal mass 2
HP:0500167 Hypergastrinemia 2
HP:0000100 Nephrotic syndrome 1
HP:0000648 Optic atrophy 1
HP:0000726 Dementia 1
HP:0000842 Hyperinsulinemia 1
HP:0000964 Eczema 1
HP:0001251 Ataxia 1
HP:0001285 Spastic tetraparesis 1
HP:0001399 Hepatic failure 1
HP:0001433 Hepatosplenomegaly 1
HP:0001873 Thrombocytopenia 1
HP:0001993 Ketoacidosis 1
HP:0002028 Chronic diarrhea 1
HP:0002039 Anorexia 1
HP:0002204 Pulmonary embolism 1
HP:0002570 Steatorrhea 1
HP:0002625 Deep venous thrombosis 1
HP:0002666 Pheochromocytoma 1
HP:0002668 Paraganglioma 1
HP:0002894 Neoplasm of the pancreas 1
HP:0003072 Hypercalcemia 1
HP:0003073 Hypoalbuminemia 1
HP:0003075 Hypoproteinemia 1
HP:0005206 Pancreatic pseudocyst 1
HP:0005213 Pancreatic calcification 1
HP:0008200 Primary hyperparathyroidism 1
HP:0010566 Hamartoma 1
HP:0011736 Primary hyperaldosteronism 1
HP:0012115 Hepatitis 1
HP:0030016 Dyspareunia 1
HP:0030318 Angular cheilitis 1
HP:0031002 Neuritis 1
HP:0032368 Acidemia 1
HP:0040192 APUdoma 1
HP:0100792 Acantholysis 1


Causative gene(s) retrieved from Orphanet

    Total: 0

Gene Symbol Gene Name Entrez Gene ID