| Rank (Similarity) |
PMID (PMCID) |
|
|---|---|---|
| 1 (59.7%) |
12394969 |
Sickle cell disease, extreme hyperbilirubinemia, and pericardial tamponade: case report and review of the literature. Khurshid I, Anderson L, Downie GH, Pape GS. Crit Care Med. 2002;30(10):2363-7. |
| Intrahepatic cholestasis Anemia Hepatomegaly Hyperbilirubinemia | ||
| Adult Anemia, Sickle Cell Cardiac Tamponade Exchange Transfusion, Whole Blood Homo sapiens Hyperbilirubinemia Intrahepatic Cholestasis Liver Failure Male | ||
| 2 (58.3%) |
1440154 |
Surgical management of children with hemoglobinopathies. Ware RE, Filston HC. Surg Clin North Am. 1992;72(6):1223-36. |
| Cholelithiasis Anemia Acidosis Sickled erythrocytes | ||
| SCN2A | ||
| Anemia, Sickle Cell Cardiac Arrest Gall Bladder Diseases Homo sapiens Male Operative Surgical Procedures Respiratory Insufficiency | ||
| 3 (57.6%) |
27366449 |
Perioperative Anaesthetic Approach in a Homozygous Sickle Cell Anaemia Patient with Frequent Pain Crises. Tuzcu K, Karcoglu M, Davarc I, Hakimoglu S, Akkucuk S. Turk J Anaesthesiol Reanim. 2014;42(6):348-51. |
| Cholelithiasis Hyperbilirubinemia Sickled erythrocytes | ||
| 4 (57.1%) |
19092326 |
Fever of unclear origin and cytopenia because of acute splenic sequestration in a young immunocompetent carrier of beta-globin mutation for Hb Valletta. Parrinello G, Torres D, Paterna S, Di Pasquale P, Licata G. Am J Med Sci. 2008;336(6):508-11. |
| Hepatosplenomegaly Splenomegaly Anemia Fever | ||
| c|SUB|A||C c|SUB|C||G | ||
| Abnormal Hemoglobins Adult Anemia Child Fever Hematological Disease Homo sapiens Immunocompetence Male Mutation Spleen beta-Globins | ||
| 5 (56.2%) |
29473172 |
Ceftriaxone-induced drug reaction mimicking acute splenic sequestration crisis in a child with hemoglobin SC disease. Van Buren NL, Gorlin JB, Reed RC, Gottschall JL, Nelson SC. Transfusion. 2018;58(4):879-883. |
| Splenomegaly Hemolytic anemia Fever | ||
| Autoantibodies Child Erythrocytes Fatal Outcome Females Hemoglobin SC Disease Homo sapiens Liver Spleen Splenomegaly | ||
| 6 (55.5%) |
17184440 |
Tramadol infusion for the pain management in sickle cell disease: a case report. Erhan E, Inal MT, Aydinok Y, Balkan C, Yegul I. Paediatr Anaesth. 2007;17(1):84-6. |
| Splenomegaly Reticulocytosis Fever | ||
| Abdominal Pain Analgesics, Non-Narcotic Analgesics, Opioid Anemia, Sickle Cell Child, Preschool Fever Hemoglobin Homo sapiens Leg Male Pain Pain Measurement Red Blood Cell Transfusion Respiratory Tract Infections Reticulocytosis Severity of Illness Index Splenomegaly Vascular Diseases | ||
| 7 (55.1%) |
21792030 |
Osteomyelitis and pyomyositis due to Pseudomonas aeruginosa in a child with sickle beta⁰-thalassemia. Krishnamurthy S, Thimmaiah S, Ramesh A, Biswal N, Menon J, Elangovan S. J Pediatr Hematol Oncol. 2011;33(6):e253-5. |
| Hepatosplenomegaly Anemia Fever | ||
| Anemia, Sickle Cell Anti-Bacterial Agents Child Homo sapiens Male Osteomyelitis Pseudomonas Infections Pseudomonas aeruginosa Pyomyositis Thalassemia | ||
| 7 (55.1%) |
15495257 |
Sickle cell crisis associated with hemophagocytic lymphohistiocytosis. Kio E, Onitilo A, Lazarchick J, Hanna M, Brunson C, Chaudhary U. Am J Hematol. 2004;77(3):229-32. |
| Hepatosplenomegaly Microcytic anemia Fever | ||
| Adult Anemia, Sickle Cell Anti-Bacterial Agents Histiocytosis, Non-Langerhans-Cell Homo sapiens Immunohistochemistry Male | ||
| 9 (54.5%) |
22802871 (3389959) |
Tuberculous spondylodiscitis in a patient with a sickle-cell disease: CT findings. Krupniewski L, Palczewski P, Golbiowski M, Kosinska-Kaczynska K. Pol J Radiol. 2012;77(1):72-6. |
| Fever Hepatomegaly Abnormal hemoglobin | ||
| 10 (54.2%) |
26989287 (4764966) |
Intracardiac Thrombosis in Sickle Cell Disease. Nikparvar M, Evazi MR, Eftekhari T, Moosavi F. Iran J Med Sci. 2016;41(2):150-3. |
| Jaundice Hemolytic anemia Fever | ||
Total: 25
| HPO ID | Term | Frequency |
|---|---|---|
| HP:0004870 | Chronic hemolytic anemia | Obligate (100%) |
| HP:0001878 | Hemolytic anemia | Very frequent (99-80%) |
| HP:0002719 | Recurrent infections | Very frequent (99-80%) |
| HP:0012531 | Pain | Very frequent (99-80%) |
| HP:0000939 | Osteoporosis | Frequent (79-30%) |
| HP:0001743 | Abnormality of the spleen | Frequent (79-30%) |
| HP:0001891 | Iron deficiency anemia | Frequent (79-30%) |
| HP:0001894 | Thrombocytosis | Frequent (79-30%) |
| HP:0001923 | Reticulocytosis | Frequent (79-30%) |
| HP:0001974 | Leukocytosis | Frequent (79-30%) |
| HP:0002754 | Osteomyelitis | Frequent (79-30%) |
| HP:0010885 | Avascular necrosis | Frequent (79-30%) |
| HP:0011981 | Pigment gallstones | Frequent (79-30%) |
| HP:0100749 | Chest pain | Frequent (79-30%) |
| HP:0000707 | Abnormality of the nervous system | Occasional (29-5%) |
| HP:0001396 | Cholestasis | Occasional (29-5%) |
| HP:0002597 | Abnormality of the vasculature | Occasional (29-5%) |
| HP:0003259 | Elevated serum creatinine | Occasional (29-5%) |
| HP:0008282 | Unconjugated hyperbilirubinemia | Occasional (29-5%) |
| HP:0011904 | Persistence of hemoglobin F | Occasional (29-5%) |
| HP:0012418 | Hypoxemia | Occasional (29-5%) |
| HP:0025435 | Increased lactate dehydrogenase activity | Occasional (29-5%) |
| HP:0001931 | Hypochromic anemia | Very rare (4-1%) |
| HP:0001935 | Microcytic anemia | Very rare (4-1%) |
| HP:0005518 | Increased mean corpuscular volume | Very rare (4-1%) |
Total: 313
| HPO ID | Term | # of case reports |
|---|---|---|
| HP:0002754 | Osteomyelitis | 57 |
| HP:0200023 | Priapism | 54 |
| HP:0001297 | Stroke | 51 |
| HP:0001903 | Anemia | 31 |
| HP:0000822 | Hypertension | 30 |
| HP:0001945 | Fever | 30 |
| HP:0002027 | Abdominal pain | 26 |
| HP:0005661 | Salmonella osteomyelitis | 19 |
| HP:0025615 | Abscess | 18 |
| HP:0002315 | Headache | 17 |
| HP:0002090 | Pneumonia | 16 |
| HP:0031864 | Bacteremia | 15 |
| HP:0100749 | Chest pain | 15 |
| HP:0100806 | Sepsis | 15 |
| HP:0001081 | Cholelithiasis | 13 |
| HP:0001406 | Intrahepatic cholestasis | 13 |
| HP:0002138 | Subarachnoid hemorrhage | 13 |
| HP:0000952 | Jaundice | 12 |
| HP:0001658 | Myocardial infarction | 11 |
| HP:0001878 | Hemolytic anemia | 11 |
| HP:0011902 | Abnormal hemoglobin | 11 |
| HP:0001909 | Leukemia | 10 |
| HP:0002099 | Asthma | 10 |
| HP:0012418 | Hypoxemia | 10 |
| HP:0000099 | Glomerulonephritis | 9 |
| HP:0001250 | Seizures | 9 |
| HP:0001978 | Extramedullary hematopoiesis | 9 |
| HP:0000100 | Nephrotic syndrome | 8 |
| HP:0000819 | Diabetes mellitus | 8 |
| HP:0000969 | Edema | 8 |
| HP:0001394 | Cirrhosis | 8 |
| HP:0001746 | Asplenia | 8 |
| HP:0004870 | Chronic hemolytic anemia | 8 |
| HP:0000488 | Retinopathy | 7 |
| HP:0000790 | Hematuria | 7 |
| HP:0002653 | Bone pain | 7 |
| HP:0003418 | Back pain | 7 |
| HP:0012115 | Hepatitis | 7 |
| HP:0002878 | Respiratory failure | 6 |
| HP:0002904 | Hyperbilirubinemia | 6 |
| HP:0012532 | Chronic pain | 6 |
| HP:0025059 | Splenic abscess | 6 |
| HP:0100584 | Endocarditis | 6 |
| HP:0001287 | Meningitis | 5 |
| HP:0001298 | Encephalopathy | 5 |
| HP:0001370 | Rheumatoid arthritis | 5 |
| HP:0001744 | Splenomegaly | 5 |
| HP:0001941 | Acidosis | 5 |
| HP:0002098 | Respiratory distress | 5 |
| HP:0002583 | Colitis | 5 |
| HP:0000093 | Proteinuria | 4 |
| HP:0000112 | Nephropathy | 4 |
| HP:0000246 | Sinusitis | 4 |
| HP:0001082 | Cholecystitis | 4 |
| HP:0001369 | Arthritis | 4 |
| HP:0001695 | Cardiac arrest | 4 |
| HP:0001873 | Thrombocytopenia | 4 |
| HP:0001907 | Thromboembolism | 4 |
| HP:0002113 | Pulmonary infiltrates | 4 |
| HP:0002140 | Ischemic stroke | 4 |
| HP:0002204 | Pulmonary embolism | 4 |
| HP:0002870 | Obstructive sleep apnea | 4 |
| HP:0003095 | Septic arthritis | 4 |
| HP:0004444 | Spherocytosis | 4 |
| HP:0011886 | Hyphema | 4 |
| HP:0030731 | Carcinoma | 4 |
| HP:0032169 | Severe infection | 4 |
| HP:0000083 | Renal insufficiency | 3 |
| HP:0000520 | Proptosis | 3 |
| HP:0000541 | Retinal detachment | 3 |
| HP:0000618 | Blindness | 3 |
| HP:0000709 | Psychosis | 3 |
| HP:0000979 | Purpura | 3 |
| HP:0001635 | Congestive heart failure | 3 |
| HP:0001944 | Dehydration | 3 |
| HP:0002094 | Dyspnea | 3 |
| HP:0002621 | Atherosclerosis | 3 |
| HP:0002721 | Immunodeficiency | 3 |
| HP:0002902 | Hyponatremia | 3 |
| HP:0006562 | Viral hepatitis | 3 |
| HP:0006859 | Posterior leukoencephalopathy | 3 |
| HP:0010550 | Paraplegia | 3 |
| HP:0010566 | Hamartoma | 3 |
| HP:0011974 | Myelofibrosis | 3 |
| HP:0025268 | Stuttering | 3 |
| HP:0030667 | Peripheral retinal neovascularization | 3 |
| HP:0100658 | Cellulitis | 3 |
| HP:0000097 | Focal segmental glomerulosclerosis | 2 |
| HP:0000135 | Hypogonadism | 2 |
| HP:0000501 | Glaucoma | 2 |
| HP:0000572 | Visual loss | 2 |
| HP:0000793 | Membranoproliferative glomerulonephritis | 2 |
| HP:0001045 | Vitiligo | 2 |
| HP:0001254 | Lethargy | 2 |
| HP:0001269 | Hemiparesis | 2 |
| HP:0001342 | Cerebral hemorrhage | 2 |
| HP:0001396 | Cholestasis | 2 |
| HP:0001399 | Hepatic failure | 2 |
| HP:0001409 | Portal hypertension | 2 |
| HP:0001433 | Hepatosplenomegaly | 2 |
| HP:0001681 | Angina pectoris | 2 |
| HP:0001735 | Acute pancreatitis | 2 |
| HP:0001750 | Single ventricle | 2 |
| HP:0001891 | Iron deficiency anemia | 2 |
| HP:0001919 | Acute kidney injury | 2 |
| HP:0001954 | Recurrent fever | 2 |
| HP:0001955 | Unexplained fevers | 2 |
| HP:0002013 | Vomiting | 2 |
| HP:0002170 | Intracranial hemorrhage | 2 |
| HP:0002176 | Spinal cord compression | 2 |
| HP:0002240 | Hepatomegaly | 2 |
| HP:0002248 | Hematemesis | 2 |
| HP:0002301 | Hemiplegia | 2 |
| HP:0002321 | Vertigo | 2 |
| HP:0002385 | Paraparesis | 2 |
| HP:0002617 | Dilatation | 2 |
| HP:0002625 | Deep venous thrombosis | 2 |
| HP:0002664 | Neoplasm | 2 |
| HP:0002716 | Lymphadenopathy | 2 |
| HP:0002758 | Osteoarthritis | 2 |
| HP:0003470 | Paralysis | 2 |
| HP:0004804 | Congenital hemolytic anemia | 2 |
| HP:0005162 | Left ventricular dysfunction | 2 |
| HP:0005293 | Venous insufficiency | 2 |
| HP:0005521 | Disseminated intravascular coagulation | 2 |
| HP:0006846 | Acute encephalopathy | 2 |
| HP:0009830 | Peripheral neuropathy | 2 |
| HP:0012378 | Fatigue | 2 |
| HP:0020110 | Bone fracture | 2 |
| HP:0025143 | Chills | 2 |
| HP:0025342 | Central retinal artery occlusion | 2 |
| HP:0030242 | Portal vein thrombosis | 2 |
| HP:0030838 | Hip pain | 2 |
| HP:0031013 | Ankylosis | 2 |
| HP:0031273 | Shock | 2 |
| HP:0031520 | Groin pain | 2 |
| HP:0031625 | Pseudoaneurysm | 2 |
| HP:0100523 | Liver abscess | 2 |
| HP:0000016 | Urinary retention | 1 |
| HP:0000031 | Epididymitis | 1 |
| HP:0000103 | Polyuria | 1 |
| HP:0000105 | Enlarged kidney | 1 |
| HP:0000124 | Renal tubular dysfunction | 1 |
| HP:0000141 | Amenorrhea | 1 |
| HP:0000486 | Strabismus | 1 |
| HP:0000651 | Diplopia | 1 |
| HP:0000725 | Psychotic episodes | 1 |
| HP:0000739 | Anxiety | 1 |
| HP:0000789 | Infertility | 1 |
| HP:0000802 | Impotence | 1 |
| HP:0000821 | Hypothyroidism | 1 |
| HP:0000823 | Delayed puberty | 1 |
| HP:0000938 | Osteopenia | 1 |
| HP:0000939 | Osteoporosis | 1 |
| HP:0000989 | Pruritus | 1 |
| HP:0001105 | Retinal atrophy | 1 |
| HP:0001123 | Visual field defect | 1 |
| HP:0001138 | Optic neuropathy | 1 |
| HP:0001508 | Failure to thrive | 1 |
| HP:0001513 | Obesity | 1 |
| HP:0001629 | Ventricular septal defect | 1 |
| HP:0001638 | Cardiomyopathy | 1 |
| HP:0001640 | Cardiomegaly | 1 |
| HP:0001648 | Cor pulmonale | 1 |
| HP:0001649 | Tachycardia | 1 |
| HP:0001657 | Prolonged QT interval | 1 |
| HP:0001678 | Atrioventricular block | 1 |
| HP:0001692 | Atrial arrhythmia | 1 |
| HP:0001694 | Right-to-left shunt | 1 |
| HP:0001701 | Pericarditis | 1 |
| HP:0001733 | Pancreatitis | 1 |
| HP:0001824 | Weight loss | 1 |
| HP:0001875 | Neutropenia | 1 |
| HP:0001876 | Pancytopenia | 1 |
| HP:0001889 | Megaloblastic anemia | 1 |
| HP:0001894 | Thrombocytosis | 1 |
| HP:0001896 | Reticulocytopenia | 1 |
| HP:0001900 | Increased hemoglobin | 1 |
| HP:0001923 | Reticulocytosis | 1 |
| HP:0001927 | Acanthocytosis | 1 |
| HP:0001959 | Polydipsia | 1 |
| HP:0001971 | Hypersplenism | 1 |
| HP:0002014 | Diarrhea | 1 |
| HP:0002017 | Nausea and vomiting | 1 |
| HP:0002019 | Constipation | 1 |
| HP:0002024 | Malabsorption | 1 |
| HP:0002039 | Anorexia | 1 |
| HP:0002045 | Hypothermia | 1 |
| HP:0002047 | Malignant hyperthermia | 1 |
| HP:0002072 | Chorea | 1 |
| HP:0002076 | Migraine | 1 |
| HP:0002093 | Respiratory insufficiency | 1 |
| HP:0002104 | Apnea | 1 |
| HP:0002149 | Hyperuricemia | 1 |
| HP:0002153 | Hyperkalemia | 1 |
| HP:0002202 | Pleural effusion | 1 |
| HP:0002318 | Cervical myelopathy | 1 |
| HP:0002352 | Leukoencephalopathy | 1 |
| HP:0002381 | Aphasia | 1 |
| HP:0002427 | Motor aphasia | 1 |
| HP:0002576 | Intussusception | 1 |
| HP:0002580 | Volvulus | 1 |
| HP:0002586 | Peritonitis | 1 |
| HP:0002588 | Duodenal ulcer | 1 |
| HP:0002615 | Hypotension | 1 |
| HP:0002634 | Arteriosclerosis | 1 |
| HP:0002637 | Cerebral ischemia | 1 |
| HP:0002650 | Scoliosis | 1 |
| HP:0002791 | Hypoventilation | 1 |
| HP:0002797 | Osteolysis | 1 |
| HP:0002835 | Aspiration | 1 |
| HP:0002862 | Bladder carcinoma | 1 |
| HP:0002883 | Hyperventilation | 1 |
| HP:0002907 | Microscopic hematuria | 1 |
| HP:0002958 | Immune dysregulation | 1 |
| HP:0002960 | Autoimmunity | 1 |
| HP:0003040 | Arthropathy | 1 |
| HP:0003074 | Hyperglycemia | 1 |
| HP:0003179 | Protrusio acetabuli | 1 |
| HP:0003326 | Myalgia | 1 |
| HP:0003401 | Paresthesia | 1 |
| HP:0003641 | Hemoglobinuria | 1 |
| HP:0004377 | Hematological neoplasm | 1 |
| HP:0004387 | Enterocolitis | 1 |
| HP:0004395 | Malnutrition | 1 |
| HP:0004418 | Thrombophlebitis | 1 |
| HP:0004787 | Fulminant hepatitis | 1 |
| HP:0004936 | Venous thrombosis | 1 |
| HP:0004942 | Aortic aneurysm | 1 |
| HP:0004947 | Arteriovenous fistula | 1 |
| HP:0005180 | Tricuspid regurgitation | 1 |
| HP:0005202 | Helicobacter pylori infection | 1 |
| HP:0005263 | Gastritis | 1 |
| HP:0005305 | Cerebral venous thrombosis | 1 |
| HP:0005523 | Lymphoproliferative disorder | 1 |
| HP:0005535 | Exercise-induced hemolysis | 1 |
| HP:0005558 | Chronic leukemia | 1 |
| HP:0005575 | Hemolytic-uremic syndrome | 1 |
| HP:0006519 | Alveolar cell carcinoma | 1 |
| HP:0007401 | Macular atrophy | 1 |
| HP:0007626 | Mandibular osteomyelitis | 1 |
| HP:0007866 | Retinal infarction | 1 |
| HP:0007902 | Vitreous hemorrhage | 1 |
| HP:0008200 | Primary hyperparathyroidism | 1 |
| HP:0008282 | Unconjugated hyperbilirubinemia | 1 |
| HP:0008940 | Generalized lymphadenopathy | 1 |
| HP:0009831 | Mononeuropathy | 1 |
| HP:0010310 | Chylothorax | 1 |
| HP:0010535 | Sleep apnea | 1 |
| HP:0010783 | Erythema | 1 |
| HP:0011458 | Abdominal symptom | 1 |
| HP:0011834 | Moyamoya phenomenon | 1 |
| HP:0011981 | Pigment gallstones | 1 |
| HP:0012085 | Pyuria | 1 |
| HP:0012089 | Arteritis | 1 |
| HP:0012223 | Splenic rupture | 1 |
| HP:0012230 | Rhegmatogenous retinal detachment | 1 |
| HP:0012324 | Myeloid leukemia | 1 |
| HP:0012375 | Chemosis | 1 |
| HP:0012474 | Carotid artery occlusion | 1 |
| HP:0012486 | Myelitis | 1 |
| HP:0012541 | Cephalohematoma | 1 |
| HP:0012587 | Macroscopic hematuria | 1 |
| HP:0012593 | Nephrotic range proteinuria | 1 |
| HP:0012636 | Retinal vein occlusion | 1 |
| HP:0012653 | Status asthmaticus | 1 |
| HP:0012735 | Cough | 1 |
| HP:0025116 | Fetal distress | 1 |
| HP:0025289 | Cervical lymphadenopathy | 1 |
| HP:0025326 | Retinal arterial occlusion | 1 |
| HP:0025439 | Pharyngitis | 1 |
| HP:0025569 | Polypoidal choroidal vasculopathy | 1 |
| HP:0025574 | Macular hemorrhage | 1 |
| HP:0025637 | Vasospasm | 1 |
| HP:0030049 | Brain abscess | 1 |
| HP:0030058 | Sickled erythrocytes | 1 |
| HP:0030149 | Cardiogenic shock | 1 |
| HP:0030162 | Glomerulomegaly | 1 |
| HP:0030171 | Perirenal hematoma | 1 |
| HP:0030243 | Hepatic vein thrombosis | 1 |
| HP:0030329 | Retinal thinning | 1 |
| HP:0030834 | Shoulder pain | 1 |
| HP:0030839 | Knee pain | 1 |
| HP:0030955 | Alcoholism | 1 |
| HP:0031352 | Chest tightness | 1 |
| HP:0031500 | Abdominal mass | 1 |
| HP:0032043 | Odynophagia | 1 |
| HP:0032283 | Disseminated nontuberculous mycobacterial infection | 1 |
| HP:0032366 | Positive direct antiglobulin test | 1 |
| HP:0040075 | Hypopituitarism | 1 |
| HP:0040264 | Jaw pain | 1 |
| HP:0040293 | Right hemiplegia | 1 |
| HP:0040319 | Dark urine | 1 |
| HP:0100014 | Epiretinal membrane | 1 |
| HP:0100026 | Arteriovenous malformation | 1 |
| HP:0100242 | Sarcoma | 1 |
| HP:0100537 | Fasciitis | 1 |
| HP:0100543 | Cognitive impairment | 1 |
| HP:0100598 | Pulmonary edema | 1 |
| HP:0100601 | Eclampsia | 1 |
| HP:0100614 | Myositis | 1 |
| HP:0100632 | Pulmonary sequestration | 1 |
| HP:0100646 | Thyroiditis | 1 |
| HP:0100665 | Angioedema | 1 |
| HP:0100699 | Scarring | 1 |
| HP:0100724 | Hypercoagulability | 1 |
| HP:0100727 | Histiocytosis | 1 |
| HP:0100758 | Gangrene | 1 |
| HP:0100769 | Synovitis | 1 |
| HP:0100820 | Glomerulopathy | 1 |
| HP:0200026 | Ocular pain | 1 |
| HP:0200120 | Chronic active hepatitis | 1 |
| HP:0410019 | Epigastric pain | 1 |